| Sumario: | The article focuses on the World Health Organization’s (WHO) Mosaic Toolkit to End Stigma and Discrimination in Mental Health, launched in October 2024 as a flexible, evidence-based framework designed to guide the design, implementation, and evaluation of anti-stigma initiatives globally. The Toolkit emphasizes leadership by people with lived experience, structured social contact, and inclusive collaboration, implemented through a cyclical process of planning, evaluation, and refinement. Challenges to its global uptake include cultural and linguistic adaptation, systemic resistance, limited funding, and the need for sustained organizational commitment. The article highlights the Toolkit’s potential as a platform for global knowledge exchange and systemic change, while underscoring that its success depends on meaningful local adaptation, stakeholder engagement, and rigorous evaluation rather than mere dissemination.
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