Emotional and Behavioural Problems Including Anxiety and Depressive Symptoms Across Tanner Stages in Girls With Central Precocious Puberty: A Retrospective Clinical Study.
Background: To examine the Tanner stage–specific patterns of psychological and behavioural problems in girls with central precocious puberty (CPP) and to identify clinical predictors of clinically significant psychological impairment. Methods: This retrospective cross-sectional study included 116 gi...
| Publicado en: | Actas Espanolas de Psiquiatria Vol. 54; no. 3; pp. 714 - 726 |
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| Autores principales: | , |
| Formato: | Artículo |
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Maria Lopez-Ibor
2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=lth&AN=196224139&site=ehost-live header: @attributes: shortDbName: lth uiTerm: 196224139 longDbName: MedicLatina uiTag: AN controlInfo: bkinfo: jinfo: jid: 11399287 IVZ jtl: Actas Espanolas de Psiquiatria issn: 11399287 maglogo: N pubinfo: dt: 2026 vid: 54 iid: 3 pid: 80014 pub: Maria Lopez-Ibor artinfo: ui: 196224139 10.62641/aep.v54i3.2205 ppf: 714 ppct: 12 formats: fmt: @attributes: type: P size: 7.2MB tig: atl: Emotional and Behavioural Problems Including Anxiety and Depressive Symptoms Across Tanner Stages in Girls With Central Precocious Puberty: A Retrospective Clinical Study. aug: au: Jin, Peili Wang, Duomei affil: Department of Pediatrics, Jiaxing Maternal and Child Health Care Hospital, 314051 Jiaxing, Zhejiang, China. sug: keyword: child luteinising hormone precocious puberty psychological problems Tanner stage ab: Background: To examine the Tanner stage–specific patterns of psychological and behavioural problems in girls with central precocious puberty (CPP) and to identify clinical predictors of clinically significant psychological impairment. Methods: This retrospective cross-sectional study included 116 girls with CPP treated between January 2020 and December 2024. Clinical data were extracted from electronic medical records. Pubertal development was classified by breast Tanner staging into stage II (n = 32), stage III (n = 42) and stages IV–V (n = 42). Psychological outcomes were evaluated using the age-standardised Child Behavior Checklist (CBCL) T-scores. For participants aged ≥7 years, depressive and anxiety symptoms were assessed using the Children’s Depression Inventory and the Screen for Child Anxiety Related Emotional Disorders. The independent predictors of clinically significant psychological problems were identified through logistic regression analysis, defined as CBCL Total Problems T-score of ≥64, and model performance was assessed using receiver operating characteristic curve analysis. Results: The mean CBCL Total Problems T-score was 58.6 ± 12.4, and 50 girls (43.1%) had clinically significant psychological problems. Psychological burden increased across Tanner stages. The CBCL Total T-scores were 52.4 ± 10.8 in stage II, 58.6 ± 11.6 in stage III and 65.8 ± 13.2 in stages IV–V (p < 0.001). The prevalence of clinically significant problems increased from 21.9% to 40.5% and 61.9% (p = 0.002). Internalising symptoms showed a stronger stage-related pattern than externalising symptoms. Early age at onset was associated with increased symptom severity (r = −0.385, p < 0.001). Multivariable analysis identified Tanner stages IV–V versus stage II (odds ratio [OR] = 2.94, 95% confidence interval [CI]: 1.44–5.99, p = 0.003), younger age at onset (OR = 0.72, 95% CI: 0.55– 0.94, p = 0.016), higher peak luteinising hormone (LH) (OR = 1.45, 95% CI: 1.08–1.95, p = 0.014) and family history of early puberty (OR = 2.18, 95% CI: 1.26–3.77, p = 0.005) as independent predictors. The prediction model showed good discrimination (area under the curve = 0.812, 95% CI: 0.738–0.886). Conclusions: Girls with CPP experience substantial psychological burden, and risk increases with pubertal stage. Advanced Tanner stage, earlier pubertal onset, increase in peak LH and family history are indicators for enhanced psychological monitoring and support. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: Y custom: Copyright of Actas Espanolas de Psiquiatria is the property of Maria Lopez-Ibor and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. item: Actas Espanolas de Psiquiatria holder: Maria Lopez-Ibor dt: @attributes: year: 2026 holdings: @attributes: islocal: N |
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