Nutritional Epigenetics of Vitamin Intake (A, B 1 , B 2 , B 3 , B 6 , B 12 , and E): Associations with Genome-Wide DNA Methylation.
Background/Objectives: DNA methylation is a key epigenetic mechanism involved in gene regulation and chromatin stability and may be influenced by nutritional exposures. However, population-level evidence regarding associations between dietary vitamin intake and genome-wide DNA methylation remains li...
| Publicado en: | Nutrients Vol. 18; no. 15; pp. 2474 - 2488 |
|---|---|
| Autores principales: | , , , , , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
MDPI
Aug2026
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=196245007&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 196245007 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 20726643 B0TT jtl: Nutrients issn: 20726643 maglogo: N pubinfo: dt: Aug2026 vid: 18 iid: 15 pid: 97109 pub: MDPI artinfo: ui: 196245007 196245007 196245007 10.3390/nu18152474 196245007 ppf: 2474 ppct: 14 formats: tig: atl: Nutritional Epigenetics of Vitamin Intake (A, B 1 , B 2 , B 3 , B 6 , B 12 , and E): Associations with Genome-Wide DNA Methylation. aug: au: Aras, Sadiye Shi, Jiajun Xu, Shuai Wu, Jie Wen, Wanqing Courtney, Regina Cai, Hui Shu, Xiao-Ou Zheng, Wei Long, Jirong Cai, Qiuyin Wang, Xiaofei affil: Department of Biological Sciences, Tennessee State University, Nashville, TN 37209, USA sug: subj: Food Intake Evaluation Epigenomics Vitamin A Thiamine Riboflavin Pyridoxine Vitamin B12 DNA Methylation Human Middle Age Female Male Cross Sectional Studies Genome Wide Association Study Blood Specimen Collection Questionnaires Life Style Race Factors Sex Factors Micronutrients Linear Regression Data Analysis Software Descriptive Statistics Funding Source Middle Aged: 45-64 years Female Male ab: Background/Objectives: DNA methylation is a key epigenetic mechanism involved in gene regulation and chromatin stability and may be influenced by nutritional exposures. However, population-level evidence regarding associations between dietary vitamin intake and genome-wide DNA methylation remains limited. Methods: We investigated associations between dietary intake of vitamins A, B1, B2, B3, B6, B12, and E and blood DNA methylation in 2030 participants from the Southern Community Cohort Study (SCCS). Dietary intake was assessed using a validated Food Frequency Questionnaire, and genome-wide DNA methylation was profiled using the Illumina Infinium MethylationEPIC v2.0 BeadChip. Epigenome-wide association analyses were conducted using robust linear regression models adjusted for demographic, lifestyle, and estimated cellular composition variables. Results: We identified 34 CpG sites associated with dietary intake of vitamins B1, B2, B3, B6, and E, at a false discovery rate-adjusted p-value (FDR_p) threshold of <0.1. The strongest association was observed between vitamin B6 intake and cg19831775 (Beta = −0.111, FDR_p = 0.015). No statistically significant associations were identified for vitamins A and B12. Most observed effects were modest, and associations were locus-specific rather than global. Race- and sex-stratified analyses demonstrated generally consistent directions of association, although statistical significance was attenuated in subgroup analyses. Conclusions: These findings provide suggestive evidence that dietary intake of vitamins B1, B2, B3, B6 and E may be associated with subtle variation in DNA methylation at specific genomic loci. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|