Resting-state EEG microstate dynamics indicate altered brain network temporal organization in age-related hearing loss.
Objective: Age-related hearing loss (ARHL) is increasingly recognized as a condition that involves changes in the central nervous system beyond the auditory pathway, with growing evidence showing altered large-scale brain network connectivity. However, how ARHL reshapes the temporal organization of...
| Publicado en: | Frontiers in Aging Neuroscience pp. 1 - 11 |
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| Autores principales: | , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Frontiers Media S.A.
2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=196246491&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 196246491 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 16634365 BG2U jtl: Frontiers in Aging Neuroscience issn: 16634365 maglogo: N pubinfo: dt: 2026 pid: 40038 pub: Frontiers Media S.A. artinfo: ui: 196246491 196246491 196246491 10.3389/fnagi.2026.1850657 196246491 ppf: 1 ppct: 10 formats: tig: atl: Resting-state EEG microstate dynamics indicate altered brain network temporal organization in age-related hearing loss. aug: au: Chen, Yurun Liu, Qiaoyu Chen, Yaohan Zhu, Min Qiao, Yufei Chen, Jiaran Sun, Wen Yang, Hua Shang, Yingying affil: Department of Otorhinolaryngology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China sug: subj: Presbycusis Pathology Electroencephalography Large-Scale Brain Networks Audiometry, Pure-Tone Human China Funding Source Severity of Illness Male Female Middle Age Aged Auditory Threshold Speech Perception Chi Square Test Unpaired T-Tests Data Analysis Software Descriptive Statistics Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Objective: Age-related hearing loss (ARHL) is increasingly recognized as a condition that involves changes in the central nervous system beyond the auditory pathway, with growing evidence showing altered large-scale brain network connectivity. However, how ARHL reshapes the temporal organization of large-scale brain networks remains poorly understood. This study aimed to investigate whether ARHL is associated with alterations in resting-state electroencephalogram (EEG) microstate dynamics and to examine the relationship between microstate features and auditory function. Methods: Resting-state EEGs were recorded in 45 older adults with ARHL and 50 age-matched normal-hearing (NH) controls. Microstate analysis was performed using a seven-class model. Group differences in microstate parameters were assessed. Correlation analyses were conducted to examine associations between microstate metrics and audiological measures, including pure-tone audiometry (PTA) thresholds and speech-in-noise (SIN) perception. Results: Compared with NH controls, participants with ARHL exhibited reduced microstate G time coverage at the nominal significance level (uncorrected p < 0.05, FDR-adjusted q ≥ 0.05). In addition, the ARHL group showed significantly (FDR-adjusted q < 0.05) increased transition probabilities (TPs) from C to F and from F to C. Conversely, the TP from D to G was significantly reduced, whereas the TP from G to D showed a reduction at the nominal significance level. Across all participants, after controlling for age and sex, microstate G time coverage and TP from D to G were negatively correlated with PTA thresholds, whereas the TPs from C to F and from F to C were positively correlated with PTA thresholds. Furthermore, microstate G time coverage showed a nominal negative correlation with the SIN threshold. Conclusion: ARHL is associated with altered resting-state EEG microstate dynamics, mainly reflected by changes in TPs among sensorimotor and higher-order cognitive networks. Resting-state EEG microstate analysis provides a comprehensive and systematic framework for studying brain network temporal reorganization induced by auditory decline. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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