| Summary: | This article focuses on a case of cryptococcal meningitis (CM) in a non-HIV patient who was subsequently diagnosed with asymptomatic low-grade follicular lymphoma, highlighting the association between CM and underlying hematologic malignancies. CM, primarily caused by Cryptococcus neoformans, typically affects immunocompromised individuals, including those with HIV, malignancies, or immunosuppressive conditions. The patient, a 72-year-old woman with multiple comorbidities, presented with neurological symptoms and was found to have CM; further investigation revealed leukopenia and generalized lymphadenopathy, leading to the diagnosis of follicular lymphoma. The report emphasizes the importance of screening for occult malignancies in older patients presenting with CM, as hematologic cancers can impair immunity before clinical manifestation, influencing treatment and prognosis.
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