Facts and figures of the compassionate use of onco-hematological drugs from 2016 to 2021: Results from the multicentric observational study Compass-O.
Background: Compassionate drug use (CDU) is a topic of debate in the scientific community characterized by a lack of information, especially in the onco-hematology area. Aim: The Compass-O study aimed to provide updated data on CDU of onco-hematological drugs for the period 2016–2021. Method: Compas...
| Publicado en: | Journal of Oncology Pharmacy Practice Vol. 32; no. 6; pp. 1008 - 1016 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Sage Publications Inc.
Sep2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=196292532&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 196292532 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10781552 0JI jtl: Journal of Oncology Pharmacy Practice issn: 10781552 maglogo: Y pubinfo: dt: Sep2026 vid: 32 iid: 6 pid: 344 pub: Sage Publications Inc. place: Thousand Oaks, California artinfo: ui: 196292532 183635195 196292532 196292532 10.1177/10781552251327117 196292532 ppf: 1008 ppct: 8 formats: tig: atl: Facts and figures of the compassionate use of onco-hematological drugs from 2016 to 2021: Results from the multicentric observational study Compass-O. aug: au: Mascolo, Annamaria Dell'Anno, Irene Dondi, Leonardo Scavone, Cristina Capuano, Annalisa Giordano, Marialuisa Cristinziano, Adriano Tarantino, Domenico Pani, Marcello Masini, Carla Donati, Caterina Rossin, Elisabetta Lagana, Graziella Ballerio, Alice Bagaglini, Gabriele Bonanni, Gabriella Vergati, Alberto Cavaliere, Arturo Celenza, Rosanna D'Arpino, Alessandro affil: Department of Experimental Medicine, Section of Pharmacology "L. Donatelli", University of Campania "Luigi Vanvitelli", Napoli, Italy sug: subj: Hematologic Diseases Drug Therapy Neoplasms Drug Therapy Antineoplastic Agents Therapeutic Use Drugs, Off-Label Drug Utilization Trends Human Male Multicenter Studies Female Nonexperimental Studies Retrospective Design Record Review Italy Lung Neoplasms Drug Therapy Nivolumab Therapeutic Use Leukemia, Myeloid, Acute Drug Therapy Azacitidine Therapeutic Use Breast Neoplasms Leukemia, Lymphocytic, Chronic Multiple Myeloma Conceptual Framework Descriptive Statistics Cost Savings Insurance, Health, Reimbursement Male Female ab: Background: Compassionate drug use (CDU) is a topic of debate in the scientific community characterized by a lack of information, especially in the onco-hematology area. Aim: The Compass-O study aimed to provide updated data on CDU of onco-hematological drugs for the period 2016–2021. Method: Compass-O is a retrospective observational study with data obtained from 7 Italian Units for cytotoxic drug preparations (Unità Farmaci Antiblastici, UFA). Drugs and Therapeutic Indications (TI) were described separately and as drug-TI combinations, providing the mean Patients Per Year (mPPY) and the Years of Use (YoU). Results: A total of 783 requests of CDU were retrieved, referring to 156.3 mPPY (max: 272 in 2021; min: 84 in 2018). The 52.2% of subjects was female, and the 63.2% aged >60 years. A total of 709 (90.5%) CDUs referred to solid tumors and 74 (9.5%) to liquid tumors. CDU referred to 93 drug-TI combinations. The most recurrent drug-TIs were nivolumab-lung carcinoma (mPPY: 36.5; YoU: 2) for solid tumors, and azacytidine-acute myeloid leukemia (6.0; 1) for liquid tumors. The most frequent TIs were lung carcinoma (45.7; 6) and breast cancer (37.0; 4) for solid tumors, and chronic lymphocytic leukemia (5.0; 2) and multiple myeloma (4.7; 6) for liquid tumors. Conclusion: Compass-O provided an updated framework of the CDU in onco-hematology, showing its large-scale phenomenon and the relevance of UFA as a data source, underlining the need for a national observatory to monitor CDU. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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