Effects of Time-Restricted Eating on Insulin Sensitivity, Glycemic Control, and Metabolic Outcomes in Low- and Middle-Income Countries: A Systematic Review.
Background: Metabolic disease is accelerating across Low- and Middle-Income Countries (LMICs), where calorie-focused dietary prescriptions frequently fail due to cost and complexity. Time-Restricted Eating (TRE) is a distinct approach. It restructures when food is eaten rather than what or how much,...
| Publicado en: | Clinical Medicine Insights: Endocrinology & Diabetes Vol. 19; pp. 1 - 16 |
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| Autores principales: | , , , |
| Formato: | research systematic review tables/charts Journal Article |
| Publicado: |
Sage Publications Inc.
8/21/2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=196383864&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 196383864 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 11795514 B3KQ jtl: Clinical Medicine Insights: Endocrinology & Diabetes issn: 11795514 maglogo: Y pubinfo: dt: 8/21/2026 vid: 19 pid: 344 pub: Sage Publications Inc. place: Thousand Oaks, California artinfo: ui: 196383864 196383864 196383864 10.1177/11795514261480411 196383864 ppf: 1 ppct: 15 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Effects of Time-Restricted Eating on Insulin Sensitivity, Glycemic Control, and Metabolic Outcomes in Low- and Middle-Income Countries: A Systematic Review. aug: au: Ampofo, Eugene Amoako, Mary Turkson, Fiifi Derrick Apprey, Charles affil: Department of Biochemistry and Biotechnology, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana sug: subj: Intermittent Fasting Restricted Diet Eating Behavior Time Factors Insulin Sensitivity Glycemic Control Metabolic Diseases Prevention and Control Low and Middle Income Countries Treatment Outcomes Anthropometry Human Systematic Review PubMed Checklists Body Weight Glycated Hemoglobin Food Intake Energy Intake ab: Background: Metabolic disease is accelerating across Low- and Middle-Income Countries (LMICs), where calorie-focused dietary prescriptions frequently fail due to cost and complexity. Time-Restricted Eating (TRE) is a distinct approach. It restructures when food is eaten rather than what or how much, limiting daily intake to a 6 to 10 hour window as a cost-free chronomedicine strategy. Its mechanisms and long-term glycemic effects in diverse LMIC populations remain incompletely synthesised. Objectives: To systematically review TRE's clinical efficacy on glycemic control, insulin sensitivity, and anthropometric outcomes across LMIC cohorts, and to evaluate molecular evidence for AMPK/mTOR pathway activation. Data Sources and Methods: A PRISMA 2020-compliant systematic review was conducted using PubMed, Scopus, and Web of Science. Eligible studies included randomised controlled trials and quasi-experimental designs involving adults in LMICs with metabolic conditions. TRE windows of 6 to 10 hours were required. Risk of bias was assessed using RoB 2.0 and ROBINS-I. The review was prospectively registered with PROSPERO (CRD420261352841). Results: Twenty-six unique cohorts (28 reports) across India, China, Indonesia, Iran, Tunisia, and Brazil were included. TRE was associated with reductions in insulin resistance, fasting blood sugar, and body weight across most included studies. A persistent HbA1c reduction of -0.78% at 18 months in one longitudinal cohort suggested that glycemic benefits may compound with sustained adherence. Contradictions emerged between centres regarding TRE's superiority over caloric restriction. Conclusion: TRE may represent a feasible, low-cost dietary strategy for metabolic health management in resource-limited settings, though further evidence from larger and longer trials is needed. Plain language summary: Millions of people in developing countries live with Type 2 Diabetes, yet expensive dietary programmes are often unaffordable. Time-Restricted Eating simply limits the hours during which food is consumed each day. This review examined 26 studies from India, China, Indonesia, Iran, Tunisia, and Brazil. Restricting eating to 6 to 10 hours daily was associated with improvements in blood sugar, reduced insulin resistance, and supported weight loss without requiring changes to food quality or supplements. Blood sugar improvements remained evident 18 months later. One small study found early signs of cellular energy changes within 20 days of starting TRE. Growing evidence suggests that the timing of meals may be as important as the content of meals in managing metabolic disease. pubtype: Academic Journal doctype: research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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