Experiences of Migraine and Erenumab Treatment in Japan: Qualitative Interviews with Clinical Trial Participants.
Background: In Japan, migraine is estimated to affect 6–8.6% of the population, and the burden of migraine and barriers to migraine care are substantial. Although new preventive treatments are available for migraine, there is limited qualitative information about the lived experience of adults with...
| Publicado en: | Patient Vol. 19; no. 5; pp. 699 - 710 |
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| Autores principales: | , , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Sep2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=196447651&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 196447651 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 11781653 91S4 jtl: Patient issn: 11781653 maglogo: N pubinfo: dt: Sep2026 vid: 19 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 196447651 193027634 196447651 196447651 10.1007/s40271-026-00813-6 196447651 ppf: 699 ppct: 11 formats: tig: atl: Experiences of Migraine and Erenumab Treatment in Japan: Qualitative Interviews with Clinical Trial Participants. aug: au: Dias-Barbosa, Carla Igarashi, Hisaka Duenas, Ashley Hareendran, Asha Kitamura, Shigekazu Tanaka, Shigeya Sanno, Naoko Doi, Hikaru Nagamitsu, Tsutomu Tatsuoka, Yoshihisa Matsumori, Yasuhiko Hasebe, Miki Takeshima, Takao affil: https://ror.org/03bndes49 PPD Evidera Patient-Centered Research, Thermo Fisher Scientific, London, UK sug: subj: Migraine Drug Therapy Migraine Symptoms Antibodies, Monoclonal Therapeutic Use Patient Attitudes Evaluation Research Subjects Randomized Controlled Trials Human Japan Funding Source Cross Sectional Studies Qualitative Studies Male Female Adult Middle Age Semi-Structured Interview Interview Guides Content Analysis Data Analysis Software Confidence Intervals Descriptive Statistics Patient Satisfaction Quality of Life Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: Background: In Japan, migraine is estimated to affect 6–8.6% of the population, and the burden of migraine and barriers to migraine care are substantial. Although new preventive treatments are available for migraine, there is limited qualitative information about the lived experience of adults with migraine in Japan and how these treatments improve their day-to-day lives. Methods: Participants in a qualitative interview study embedded in a phase 3 randomized, double-blind, placebo-controlled clinical trial (NCT03812224) were invited to take part in a telephone interview after completing 24 weeks of double-blind treatment with once-monthly erenumab 70 mg and a subsequent 28-week open-label treatment period. Interviews were conducted by Japanese interviewers using a semi-structured interview guide. The interviews were audio-recorded, transcribed, and qualitatively analysed using a thematic content analysis approach. Results: Forty-one participants were interviewed between May and September 2020. The mean age of participants was 43.8 years; 82.9% were female, 51.2% had episodic migraine, and 48.8% had chronic migraine. Prior to trial participation, patients identified pain, nausea, and profound tiredness—often expressed as a "lack of energy" or feeling "exhausted" or "drained"—as the most bothersome symptoms. Patients also emphasized difficulties concentrating, interference with school, work, and household responsibilities, and emotional strain as the most bothersome impacts of living with migraine. At the end of the trial, patients reported important improvements in their migraine experience—such as reductions in migraine frequency, severity, and duration—which translated into tangible benefits in daily life. Overall, satisfaction with erenumab was high (mean score 6.8 on a 0–10 scale) and was mainly driven by the reduced frequency and duration of migraine. Conclusion: Results from this qualitative study confirm that migraine significantly impacts the quality of life of adults in Japan. This study provides valuable insights into patients' experiences of erenumab, which reduced the frequency, severity, or duration of migraine episodes in most patients, resulting in better functioning and overall quality of life. Trial Registration: Clinicaltrials.gov NCT03812224. Registered January 23, 2019. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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