Fabrication and characterization of spin-coated multilayer surface-eroding implants for automated multi-pulse drug delivery.
Medication nonadherence contributes to disease progression, avoidable hospitalization, and an estimated $100–300 billion in annual excess healthcare costs in the United States. Implants that encode a dosing schedule during fabrication offer an alternative to patient-dependent administration. Here we...
| Publicado en: | Biomedical Microdevices Vol. 28; no. 3; pp. 1 - 21 |
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| Autores principales: | , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Sep2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=196774468&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 196774468 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 13872176 ODN jtl: Biomedical Microdevices issn: 13872176 maglogo: N pubinfo: dt: Sep2026 vid: 28 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 196774468 10.1007/s10544-026-00848-4 196774468 ppf: 1 ppct: 20 formats: tig: atl: Fabrication and characterization of spin-coated multilayer surface-eroding implants for automated multi-pulse drug delivery. aug: au: Brewster, Parker R. Nevils, Katherine Ates, Lilly Sellers, Acelynn Stevens, Heath Alazzam, Omayma Walker, Glenn M. Werfel, Thomas A. affil: https://ror.org/02teq1165 Department of Biomedical Engineering, University of Mississippi, 38677, University, MS, USA sug: ab: Medication nonadherence contributes to disease progression, avoidable hospitalization, and an estimated $100–300 billion in annual excess healthcare costs in the United States. Implants that encode a dosing schedule during fabrication offer an alternative to patient-dependent administration. Here we apply spin coating to build multilayer surface-eroding implants from cellulose acetate phthalate (CAP) and Pluronic F-127, stacking fluorescein-loaded poly(vinyl alcohol) active layers between degradable CAP–Pluronic composite (CAPP) barrier layers whose thickness sets the interval between release events. Spin-curve calibration gave an inverse power-law dependence of thickness on rotational speed (R² = 0.979) from 436 ± 9 to 92 ± 4 μm. Against solvent-cast films produced from a necessarily different formulation at a matched 400 μm nominal target, spin coating reduced batch-to-batch standard deviation from approximately 34 to 2 μm and within-film standard deviation from 43–47 to 5–12 μm (n = 3 independently fabricated films per method); at a 100 μm target it reduced the maximum surface excursion below the mean plane, measured by atomic force microscopy, from 146.1 to 4.5 nm; confocal Raman mapping showed the standard deviation of the CAP/F-127 peak-height ratio falling from 2.91 to 0.77. Two device configurations, designated Q16 and Q72 after the approximately 16 and 72 h inter-pulse intervals they produced, each gave three discrete release events with near-baseline inter-pulse signal (n = 6 devices per condition). pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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