Cover Image
QR Code

A DFT/CDM Study of Metal-Carboxylate Interactions in Metalloproteins: Factors Governing the Maximum Number of Metal-Bound Carboxylates.

The number of negatively charged metal-bound Asp/GIu residues determines the net charge of the carboxylate-rich metal-binding site, which has been found to play a role in enhancing the affinity and/or selectivity of a protein cavity for a given metal cofactor. Therefore, it is of interest to know th...

Full description

Published in:Journal of the American Chemical Society Vol. 128; no. 5; pp. 1533 - 1562
Main Authors: Dudev, Todor, Lim, Carmay
Format: Article
Published: American Chemical Society 2/8/2006
Subjects:
Metalloproteins
Organometallic compounds
Density functionals
Proteins
Ligands (Chemistry)
Coordination compounds
Online Access:View this record in EBSCOhost