Stereocontrolled Synthesis of Spiroketals via Ti(Oi-Pr)-Mediated Kinetic Spirocyclization of Glycal Epoxides with Retention of Configuration.

The article discusses the stereocontrolled synthesis of spiroketals. It is observed that alternate nonchelated mechanisms are inconsistent with the observed stereochemical preference. Kinetic spiroketalization is Mediated cyclization of Ti(Oi-Pr)4 and MeOH-induced cyclization (C1-inversion) provide...

Descripción completa

Detalles Bibliográficos

Publicado en:	Journal of the American Chemical Society Vol. 128; no. 6; pp. 1792 - 1794
Autores principales:	Moilanen, Sirkka B., Potuzak, Justin S., Tan, Derek S.
Formato:	Artículo
Publicado:	American Chemical Society 2/15/2006
Materias:	Chemical kinetics Ring formation (Chemistry) Reaction mechanisms (Chemistry) Occlusal adjustment Chemical reactions Substitution reactions
Acceso en línea:	Ver este registro en EBSCOhost