Cell-Permeable and Biocompatible Polymeric Nanoparticles for Apoptosis Imaging.

The article examines the synthesis and characteristics of cell-permeable and biocompatible polymeric nanoparticles for apoptosis imaging. The study shows that this polymeric nanoparticle was efficiently and specifically cleaved by both caspase-3 and caspase 7 in cell-free condition and cell culture...

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Publicado en:Journal of the American Chemical Society Vol. 128; no. 11; pp. 3490 - 3492
Autores principales: Kwangmeyung Kim, Misu Lee, Hyungkyu Park, Jong-Ho Kim, Sungwon Kim, Hesson Chung, Kuiwon Choi, In-San Kim, Seong, Balk L., Ick Chan Kwofl
Formato: Artículo
Publicado: American Chemical Society 3/22/2006
Materias:
Acceso en línea:Ver este registro en EBSCOhost
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      pub: American Chemical Society
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        10.1021/ja057712f
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        atl: Cell-Permeable and Biocompatible Polymeric Nanoparticles for Apoptosis Imaging.
      aug:
        au:
          Kwangmeyung Kim
          Misu Lee
          Hyungkyu Park
          Jong-Ho Kim
          Sungwon Kim
          Hesson Chung
          Kuiwon Choi
          In-San Kim
          Seong, Balk L.
          Ick Chan Kwofl
        affil:
          Biomedical Research Center, Korea Institute of Science and Technology, 39-1 Haweolgog-Dong, Sungbook-Gu, Seoul 136-791, Korea
          Department of Biotechnology, College of Engineering, Yonsei University, Korea
          Advanced Medical Technology Cluster for Diagnosis & Prediction, Kyungpook National University, Korea
      su:
        Nanoparticles
        Biocompatibility
        Apoptosis
        Imaging systems
        Cell culture
      sug:
        subj:
          Nanoparticles
          Biocompatibility
          Apoptosis
          Imaging systems
          Cell culture
      ab: The article examines the synthesis and characteristics of cell-permeable and biocompatible polymeric nanoparticles for apoptosis imaging. The study shows that this polymeric nanoparticle was efficiently and specifically cleaved by both caspase-3 and caspase 7 in cell-free condition and cell culture system. The nanoparticle can be used to measure apoptosis in cell-based high-throughput screens.
      pubtype: Academic Journal
      doctype: Article
      src: R
    language: English
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