Dos décadas de Helicobacter pylori.

Bacterial diseases are generally considered as serious sanitary problems. However, they can often be eradicated by using an antibiotic therapy. The healing of fungal and viral diseases is much more complicated. Many cancers can be cured if there is an early diagnosis, but the treatment of most of th...

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Publicado en:Revista VacciMonitor (Vacunología y Temas Afines) Vol. 12; no. 1; pp. 1 - 11
Autores principales: Cava, Felipe, Cobas, Guillermo
Formato: Artículo
Publicado: Vacunas Finlay S.A. Jan2003
Materias:
Acceso en línea:Ver este registro en EBSCOhost
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        atl: Dos décadas de Helicobacter pylori.
      aug:
        au:
          Cava, Felipe
          Cobas, Guillermo
        affil:
          Centro de Biología Molecular "Severo Ochoa", Universidad Autónoma de Madrid. Madrid. España
          Centro de Estudios de Biotecnología Universidad de Oriente. Santiago de Cuba. Cuba
      su:
        Helicobacter pylori
        Bacterial diseases
        Virus diseases
        Communicable diseases
        Heart diseases
        Antibiotics
      sug:
        subj:
          Helicobacter pylori
          Bacterial diseases
          Virus diseases
          Communicable diseases
          Heart diseases
          Antibiotics
      keyword:
        infection
        pathogenesis
        Helicobacter pylori
        infección
        patogénesis
      ab:
        Bacterial diseases are generally considered as serious sanitary problems. However, they can often be eradicated by using an antibiotic therapy. The healing of fungal and viral diseases is much more complicated. Many cancers can be cured if there is an early diagnosis, but the treatment of most of them is almost as harmful as the disease itself. Other diseases, such as the autoimmune and heart diseases are simply controlled by trying to palliate the symptoms with very expensive medicine. That's why we must understand the astonishment of the medical community when a disease, long time considered incurable, although controllable, was found to be caused by a bacterium. This was even more so, because the stomach's environment was considered too extreme to harbor any microbial life. Helicobacter pylori is the main agent of ulcer formation in the world population. Its colonization capacity and adaptability to hostile environments have allowed it to survive and grow in the harsh conditions of the stomach. In this review we briefly examine important aspects of the history of the discovery of such a relevant microorganism, as well as some molecular and clinical features of the pathology it produces.
        Las enfermedades bacterianas son generalmente consideradas como problemas sanitarios serios, sin embargo, pueden a menudo solucionarse mediante una simple terapia antibiótica. Mucho más complicada es la curación de enfermedades fúngicas y virales. Muchos cánceres se pueden curar si el diagnóstico es temprano, pero la mayoría tienen un remedio casi tan perjudicial como la misma enfermedad. Otras enfermedades como las autoinmunes o las que afectan el corazón, simplemente son controladas, tratando de paliar los síntomas con medicamentos normalmente muy costosos. Por tanto, tenemos que comprender la sorpresa de la comunidad médica, cuando una enfermedad por mucho tiempo pensada incurable aunque controlable, se vio que estaba causada por una bacteria. Más aún, cuando desde siempre se había pensado que el microambiente del estómago era demasiado extremo como para albergar vida microbiana. Helicobacter pylori es la principal responsable de la formación de úlceras en la población mundial. Su capacidad de colonización y adaptación a ambientes hostiles le ha permitido sobrevivir y crecer en las condiciones adversas que ofrece el estómago. En esta revisión se resumen brevemente aspectos importantes de la historia del descubrimiento de tan relevante microorganismo, así como algunas características moleculares y clínicas de la patología que causa.
      pubtype: Academic Journal
      doctype: Article
      src: R
    language: Spanish
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