Thermal [1,5] Hydrogen Sigmatropic Shifts in cis,cis-1,3-Cyclononadienes Probed by Gas-Phase Kinetic Studies and Density Functional Theory Calculations.

The kinetics of gas-phase thermal [1,5] hydrogen shifts interconverting the five isomeric mono-deuterium-labeled cis, cis-1,3-cyclononadienes have been followed at four temperatures from 240 to 287 °C. The activation parameters found were E = 37.1 ± 0.8 kcal/mol, log A = 11.6 ± 0.3, ΔH† = 36.0 ± 0.8...

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Publicado en:Journal of the American Chemical Society Vol. 128; no. 46; pp. 14854 - 14863
Autores principales: Baldwin, John E., Raghavan, Anuradha S., Hess Jr., B. Andes, Smentek, Lidia
Formato: Artículo
Publicado: American Chemical Society 11/22/2006
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Acceso en línea:Ver este registro en EBSCOhost
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      dt: 11/22/2006
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        10.1021/ja065656s
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        atl: Thermal [1,5] Hydrogen Sigmatropic Shifts in cis,cis-1,3-Cyclononadienes Probed by Gas-Phase Kinetic Studies and Density Functional Theory Calculations.
      aug:
        au:
          Baldwin, John E.
          Raghavan, Anuradha S.
          Hess Jr., B. Andes
          Smentek, Lidia
        affil:
          Departments of Chemistry, Syracuse University, Syracuse, New York 13244
          Vanderbilt University, Nashville, Tennessee 37235
          Institute of Physics, Nicolaus Copernicus University, 87-100 Toruń, Poland
      su:
        Chemical kinetics
        Deuterium
        Density functionals
        Isomerization
        Functional analysis
        Isomerism
      sug:
        subj:
          Chemical kinetics
          Deuterium
          Density functionals
          Isomerization
          Functional analysis
          Isomerism
      ab: The kinetics of gas-phase thermal [1,5] hydrogen shifts interconverting the five isomeric mono-deuterium-labeled cis, cis-1,3-cyclononadienes have been followed at four temperatures from 240 to 287 °C. The activation parameters found were E = 37.1 ± 0.8 kcal/mol, log A = 11.6 ± 0.3, ΔH† = 36.0 ± 0.8 kcal/mol, and ΔS† = -9.0 ± 0.3 eu. Density functional theory based calculations have provided geometries and energies for the ground-state cyclononadiene conformational isomers, for the transition states linking one to another, and for the transition states for [1,5] hydrogen shifts responsible for isomerizations among the five labeled dienes. A generalized formulation of the Winstein-Holness equation is presented and applied to the complex system, one that involves 11 ground-state conformers, 10 transition states separating them, and five transition states for [1,5] hydrogen shifts. The value for the empirical Ea derived from calculated mole fractions of ground-state conformers and calculated energies for specific ground-state conformers and [1,5] hydrogen shift transition structures was 37.5 kcal/mol, in excellent agreement with the experimentally obtained activation energy. The significance of conformational options in various ground states and transition structures for the [1,5] hydrogen shifts is considerable, an inference that may well have general applicability.
      pubtype: Academic Journal
      doctype: Article
      src: R
    language: English
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          year: 2006
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