On the Evolution and Dynamics of Biological Networks.
Large numbers of interacting non-genic molecules regulate metabolism and embryonic morphogenesis through often unspecific mechanisms. This lack of specificity suggests that the prevailing viewpoint, that such ordered processes result from the direct control of genes and their products irrespective o...
| Published in: | Biology Forum / Rivista di Biologia Vol. 100; no. 1; pp. 93 - 119 |
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| Format: | Article |
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Fabrizio Serra Editore
2007
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=hlh&AN=25887731&site=ehost-live header: @attributes: shortDbName: hlh uiTerm: 25887731 longDbName: Humanities International Complete uiTag: AN controlInfo: bkinfo: jinfo: jid: 18256538 M1F jtl: Biology Forum / Rivista di Biologia issn: 18256538 maglogo: N pubinfo: dt: 2007 vid: 100 iid: 1 pid: 50689 pub: Fabrizio Serra Editore artinfo: ui: 25887731 ppf: 93 ppct: 26 formats: fmt: @attributes: type: P size: 204KB tig: atl: On the Evolution and Dynamics of Biological Networks. aug: au: Hollenberg, Dennis su: Morphogenesis -- Molecular aspects Molecular dynamics Ecological genetics Molecular genetics Molecular biology sug: subj: Morphogenesis -- Molecular aspects Molecular dynamics Ecological genetics Molecular genetics Molecular biology keyword: determinism Ecological dynamics indirect control self-optimization ultranetwork effect ab: Large numbers of interacting non-genic molecules regulate metabolism and embryonic morphogenesis through often unspecific mechanisms. This lack of specificity suggests that the prevailing viewpoint, that such ordered processes result from the direct control of genes and their products irrespective of local molecular dynamics, is incomplete. Proposed here is a hypothetical type of control dynamics, called indirect, that is exhibited in natural biological networks of interacting and adapting elements. Evidence in the literature suggests that ordinary interactions among such elements -- including organisms, cells and molecules -- produce six network phenomena that can be attributed to indirect-control dynamics. Although these hypotheses can be disproved, including by showing that the phenomena can be accounted for by an alternative process, the set of ecological dynamics argued to underlie the phenomena is observable, biologically consistent and universal. In contrast, the direct-control dynamics required by the modern synthesis likely is biologically disadvantageous. This biological view of networks suggests new areas of research. Il metabolismo e lo sviluppo embrionale sono largamente regolati dall'interazione di molecole non-geniche, spesso attraverso meccanismi non specifici. Una tale mancanza di specificità suggerisce che la visione prevalente secondo la quale questi processi ordinati sarebbero il risultato di un controllo diretto da parte dei geni e dei loro prodotti sia in realtà incompleta. Nel presente lavoro si ipotizza che questi processi siano soggetti ad un "controllo indiretto", una forma di controllo dinamico che si osserva nelle reti biologiche naturali. Viene inoltre suggerito che le interazioni ordinarie tra gli elementi -- organismi, cellule o molecole -- producano sei fenomeni di rete che possono essere ricondotti ad una dinamica di controllo indiretto. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: Y custom: Copyright of Biology Forum / Rivista di Biologia is the property of Fabrizio Serra Editore and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. item: Biology Forum / Rivista di Biologia holder: Fabrizio Serra Editore dt: @attributes: year: 2007 holdings: @attributes: islocal: N |
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