Stacking Interactions and the Twist of DNA.
The importance of stacking interactions for the Twist and stability of DNA is investigated using the fully ab initio van der Waals density functional (vdW-DF). Our results highlight the role that binary interactions between adjacent sets of base pairs play in defining the sequence-dependent Twists o...
| Publicado en: | Journal of the American Chemical Society Vol. 130; no. 4; pp. 1304 - 1309 |
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| Autores principales: | , , , , , |
| Formato: | Artículo |
| Publicado: |
American Chemical Society
1/30/2008
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=hlh&AN=29436585&site=ehost-live header: @attributes: shortDbName: hlh uiTerm: 29436585 longDbName: Humanities International Complete uiTag: AN controlInfo: bkinfo: jinfo: jid: 00027863 ACS jtl: Journal of the American Chemical Society issn: 00027863 maglogo: N pubinfo: dt: 1/30/2008 vid: 130 iid: 4 pid: 997 pub: American Chemical Society artinfo: ui: 29436585 10.1021/ja0761941 ppf: 1304 ppct: 5 formats: tig: atl: Stacking Interactions and the Twist of DNA. aug: au: Cooper, Valentino R. Thonhauser, Timo Puzder, Aaron Schroder, Elsebeth Lundqvist, Bengt I. Langreth, David C. affil: Rutgers University Chalmers University of Technology Technical University of Denmark su: Nucleotide sequence Nucleic acid analysis Genetic code Molecular association DNA-protein interactions sug: subj: Nucleotide sequence Nucleic acid analysis Genetic code Molecular association DNA-protein interactions ab: The importance of stacking interactions for the Twist and stability of DNA is investigated using the fully ab initio van der Waals density functional (vdW-DF). Our results highlight the role that binary interactions between adjacent sets of base pairs play in defining the sequence-dependent Twists observed in high-resolution experiments. Furthermore, they demonstrate that additional stability gained by the presence of thymine is due to methyl interactions with neighboring bases, thus adding to our understanding of the mechanisms that contribute to the relative stability of DNA and RNA. Our mapping of the energy required to twist each of the 10 unique base pair steps should provide valuable information for future studies of nucleic acid stability and dynamics. The method introduced will enable the nonempirical theoretical study of significantly larger pieces of DNA or DNA/amino acid complexes than previously possible. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: Y dt: @attributes: year: 2008 holdings: @attributes: islocal: N |
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