Actividad antifúngica in vitro de la anidulafungina.
Anidulafungin is a new and very useful pharmacological tool for the treatment of invasive mycoses. The antifungal spectrum of anidulafungin reaches the most common pathogenic fungi. Anidulafungin is especially active against the genera Candida and Aspergillus. Its antifungal mechanism is based on th...
| Published in: | Revista Iberoamericana de Micologia Vol. 25; no. 2; pp. 83 - 92 |
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| Main Authors: | , |
| Format: | Article |
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Elsevier B.V.
jun2008
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| Subjects: | |
| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=lth&AN=32170082&site=ehost-live header: @attributes: shortDbName: lth uiTerm: 32170082 longDbName: MedicLatina uiTag: AN controlInfo: bkinfo: jinfo: jid: 11301406 PVP jtl: Revista Iberoamericana de Micologia issn: 11301406 maglogo: N pubinfo: dt: jun2008 vid: 25 iid: 2 pid: 467 pub: Elsevier B.V. artinfo: ui: 32170082 ppf: 83 ppct: 9 formats: fmt: @attributes: type: P size: 4.3MB tig: atl: Actividad antifúngica in vitro de la anidulafungina. aug: au: Quindós, Guillermo Eraso, Elena affil: Laboratorio de Micología médica, Departamento de Immunología, Microbiología y Parasitología, Facultad de Medicina y Odontología, Universidad del País Vasco, Bilbao, España su: Antifungal agents Anti-infective agents Candida Aspergillus Fungi sug: subj: Antifungal agents Anti-infective agents Candida Aspergillus Fungi keyword: Anidulafungin In vitro activity Moulds Yeasts Actividad in vitro Anidulafungina Antifúngico Aspergillus Candida Levaduras Mohos ab: Anidulafungin is a new and very useful pharmacological tool for the treatment of invasive mycoses. The antifungal spectrum of anidulafungin reaches the most common pathogenic fungi. Anidulafungin is especially active against the genera Candida and Aspergillus. Its antifungal mechanism is based on the inhibition of the β-1,3-D-glucan synthesis, an essential molecule for the cell wall architecture, with different consequences for Candida and Aspergillus, being anidulafungin fungicide for the former and fungistatic for the latter. This review describes the in vitro antifungal spectrum of anidulafungin based in the scientific and medical literature of recent years, We can underline that most than 99% of Candida isolates are susceptible to ≥ 2 µg/ml of anidulafungin. MIC are very low (≥ 0.125 µg/ml) for most clinical isolates of the species Candida albicans, Candida glabrata, Candida tropicalis and Candida krusei while Candida parapsilosis and Candida guilliermondii isolates are susceptible to anidulafungin concentrations ≥ 2 µg/ml. An excellent activity of anidulafungin has been also described against Aspergillus, Pneumocystis and other fungi. However, its activity is very low against Cryptococcus and the Zygomycetes. The excellent activity of anidulafungin has made this antifungal a first line therapeutic indication for candidemia and invasive candidiasis in non-neutropenic patients. La anídulafungina es una nueva y eficaz aportación farmacológica para el tratamiento de las micosis invasoras. La anidulafungina tiene un espectro antifúngico que engloba a los hongos patógenos más comunes y especialmente a los géneros Candida y Aspergillus. Su mecanismo de acción se basa en la inhibición de la síntesis de β-1,3-D-glucano, molécula esencial para la pared fúngica. Este mecanismo tiene como consecuencia dos tipos de acciones: una acción fungicida contra Candida y una acción fungistática contra Aspergillus y otros hongos filamentosos. En esta revisión se describe el espectro antifúngico in vitro de anidulafungina tomando como base los datos publicados en los últimos años. Destaca que más del 99% de los aislamientos de Candida son sensibles a concentraciones menores o iguales de 2 µg/ml de anidulafungina. Dentro de esta sensibilidad in vitro a la anidulafungina, las CMI observadas son más bajas para Candida albicans, Candida glabrata, Candida tropicalis y Candida krusei mientras que Candida parapsilosis y Candida guilliermondii son sensibles a concentraciones menores o iguales de 2 µg/ml. También se ha descrito una actividad excelente frente a Aspergillus, Pneumocystis y otros hongos. Sin embargo, su actividad es prácticamente nula contra Cryptococcus y los zigomicetos. Esta excelente actividad antifungica hace que la anidulafungina sea una indicación terapéutica de primera línea para el tratamiento de las candidemias y candidiasis invasoras en pacientes sin neutropenia. pubtype: Academic Journal doctype: Article src: R language: Spanish refInfo: copyright: @attributes: flag: Y custom: Copyright of Revista Iberoamericana de Micologia is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. item: Revista Iberoamericana de Micologia holder: Elsevier B.V. dt: @attributes: year: 2008 holdings: @attributes: islocal: N |
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