Potencial de anidulafungina en la terapia de receptores de trasplante de órgano sólido.
Anidulafungin is a new echinocandin recently approved for the treatment of esophageal candidiasis, candidemia and other forms of invasive candidiasis, such as peritonitis and intra-abdominal abscesses in non-neutropenic patients. It is fungicidal against Candida spp and fungistatic against Aspergill...
| Publicado en: | Revista Iberoamericana de Micologia Vol. 25; no. 2; pp. 129 - 134 |
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| Autores principales: | , |
| Formato: | Artículo |
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Elsevier B.V.
jun2008
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=lth&AN=32170088&site=ehost-live header: @attributes: shortDbName: lth uiTerm: 32170088 longDbName: MedicLatina uiTag: AN controlInfo: bkinfo: jinfo: jid: 11301406 PVP jtl: Revista Iberoamericana de Micologia issn: 11301406 maglogo: N pubinfo: dt: jun2008 vid: 25 iid: 2 pid: 467 pub: Elsevier B.V. artinfo: ui: 32170088 10.1016/S1130-1406(08)70031-7 ppf: 129 ppct: 5 formats: fmt: @attributes: type: P size: 567KB tig: atl: Potencial de anidulafungina en la terapia de receptores de trasplante de órgano sólido. aug: au: Abete, Jesús Fortún Martín-Dávila, Pilar affil: Servicio de Enfermedades Infecciosas, Hospital Ramón y Cajal, Madrid su: Antifungal agents Transplantation of organs, tissues, etc. Candidiasis Aspergillus Mycoses sug: subj: Antifungal agents Transplantation of organs, tissues, etc. Candidiasis Aspergillus Mycoses keyword: Anidulafungin Candida Echinocandins Transplant Anidulafungina Candida Equinocandinas Trasplante ab: Anidulafungin is a new echinocandin recently approved for the treatment of esophageal candidiasis, candidemia and other forms of invasive candidiasis, such as peritonitis and intra-abdominal abscesses in non-neutropenic patients. It is fungicidal against Candida spp and fungistatic against Aspergillus spp. It is active against Pneumocystis jirovecii. In contrast, anidulafungin does not have activity against Cryptococcus neoformans, Zygomycetes or molds, other than Aspergillus spp. The drug is well tolerated, even in patients with renal or hepatic impairment, in contrast to other echinocandins, it does not significantly interfere with the cytochrome P450 pathway and has a low drug-drug interaction profile, including calcineurinic agents and other drugs used in transplant recipients. So far, anidulafungin appears to have an excellent safety profile with few adverse events and it promises a special consideration in the management of fungal infections happening in transplant recipients. La anidulafungina es una nueva equinocandina aceptada para el tratamiento de candidiasis esofágica, candidemia y otras formas de candidiasis, como peritonitis o abscesos intraabdominales en pacientes no neutropénicos. Como las otras equinocandinas, posee una elevada actividad fungicida frente a la mayoría de las especies de Candida y es fungistático frente a Aspergillus spp. También tiene buena actividad frente a Pneumocystis jirovecii y es poco activa frente a Cryptococcus neoformans, mucorales y otros hongos filamentosos diferentes a Aspergillus spp. Presenta ausencia o mínima toxicidad renal y/o hepática y, a diferencia de otras equinocandinas y azoles, no sufre metabolización asociada con el citocromo P450. Por tanto, carece de interacciones medicamentosas con los calcineurinicos y otros fármacos utilizados en los pacientes trasplantados. Esta característica permite a la anidulafungina posicionarse como un antifúngico especialmente interesante en este tipo de pacientes. pubtype: Academic Journal doctype: Article src: R language: Spanish refInfo: copyright: @attributes: flag: Y custom: Copyright of Revista Iberoamericana de Micologia is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. item: Revista Iberoamericana de Micologia holder: Elsevier B.V. dt: @attributes: year: 2008 holdings: @attributes: islocal: N |
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