Targeting Metastable Coiled-Coil Domains by Computational Design.

Approximately 30% of eukaryotic genomes are predicted to encode partially unfolded proteins. Many of these unstructured domains contact multiple partners in short-lived interactions critical for cellular homeostasis. Understanding the functional implications of these transient binding events is a cu...

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Bibliographic Details

Published in:	Journal of the American Chemical Society Vol. 130; no. 36; pp. 12038 - 12045
Main Authors:	Barth, Patrick, Schoeffler, Allyn, Alber, Tom
Format:	Article
Published:	American Chemical Society 9/10/2008
Subjects:	Genomes Proteins Homeostasis Chemical inhibitors Peptides
Online Access:	View this record in EBSCOhost