Density Functional Theory Study on a Missing Piece in Understanding of Heme Chemistry: The Reaction Mechanism for Indoleamine 2,3-Dioxygenase and Tryptophan 2,3-Dioxygenase.

Indoleamine 2,3-dioxygenase (IDO) and tryptophan 23-dioxygenase (TDO) are heme-containing dioxygenases and catalyze oxidative cleavage of the pyrrole ring of L-tryptophan. On the basis of three recent crystal structures of these heme-containing dioxygenases, two new mechanistic pathways were propose...

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Publicado en:	Journal of the American Chemical Society Vol. 130; no. 37; pp. 12299 - 12310
Autores principales:	Chung, Lung Wa, Li, Xin, Sugimoto, Hiroshi, Shiro, Yoshitsugu, Morokuma, Keiji
Formato:	Artículo
Publicado:	American Chemical Society 9/17/2008
Materias:	Density functionals Heme oxygenase Heme Tryptophan oxygenase Tryptophan Electrophiles Imidazoles
Acceso en línea:	Ver este registro en EBSCOhost