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Structural Analysis of the Mn(IV)/Fe(III) Cofactor of Chiamydia trachomatis Ribonucleotide Reductase by Extended X-ray Absorption Fine Structure Spectroscopy and Density Functional Theory Calculations.

The class Ic ribonucleotide reductase from Chiamydia trachomatis (Ct) uses a stable Mn(lV)/Fe(lll) cofactor to initiate nucleotide reduction by a free-radical mechanism. Extended X-ray absorption fine structure (EXAFS) spectroscopy and density functional theory (OFT) calculations are used to postula...

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Published in:Journal of the American Chemical Society Vol. 130; no. 45; pp. 15022 - 15028
Main Authors: Younker, Jarod M., Krest, Courtney M., Jiang, Wel, Krebs, Carsten, Bollinger Jr., J. Martin, Green, Michael T.
Format: Article
Published: American Chemical Society 11/12/2008
Subjects:
Structural analysis (Science)
Manganese
Iron
Deoxyribonucleotides
Extended X-ray absorption fine structure
Density functionals
Proton transfer reactions
Metal ions
Online Access:View this record in EBSCOhost