Frequency and characterization of vapD gene in Helicobacter pylori strains of different vacA and cag-PAI genotype.
Several studies using different molecular-typing techniques have demonstrated that the gene content and the chromosomal arrangement among Helicobacter pylori strains are highly variable. Furthermore, this variability has been observed in different genes, such as vacA, which has a mosaic structure, a...
| Publicado en: | Revista Neurologia, Neurocirugia y Psiquiatria Vol. 41; no. 2; pp. 43 - 51 |
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| Autores principales: | , , , , , |
| Formato: | Artículo |
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Sociedad Mexicana de Neurologia y Psiquiatria A.C.
abr-jun2008
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=lth&AN=35521618&site=ehost-live header: @attributes: shortDbName: lth uiTerm: 35521618 longDbName: MedicLatina uiTag: AN controlInfo: bkinfo: jinfo: jid: 00283851 RXD jtl: Revista Neurologia, Neurocirugia y Psiquiatria issn: 00283851 maglogo: N pubinfo: dt: abr-jun2008 vid: 41 iid: 2 pid: 27959 pub: Sociedad Mexicana de Neurologia y Psiquiatria A.C. artinfo: ui: 35521618 ppf: 43 ppct: 8 formats: fmt: @attributes: type: P size: 216KB tig: atl: Frequency and characterization of vapD gene in Helicobacter pylori strains of different vacA and cag-PAI genotype. aug: au: Morales-Espinosa, Rosario González-Valencia, Gerardo Delgado, Gabriela Méndez, José Luis Torres, Javier Cravioto, Alejandro affil: Lab of Molecular Epidemiological and Bacterial Genomic. Department of Microbiology and Parasitology Unit of Medical Investigation in Infectious and Parasitological Diseases, Instituto Mexicano del Seguro Social, XXI. Mexico City, Mexico Department of Public Health. Faculty of Medicine, Universidad Nacional Autónoma de México. Mexico City su: Helicobacter pylori Infection Genes Abdominal pain Mexico sug: subj: Mexico Helicobacter pylori Infection Genes Abdominal pain keyword: cag-PAI multiple infections vacA vapD typing cag-PAI genotipos de vacA Helicobacter pylori infección múltiple vapD ab: Several studies using different molecular-typing techniques have demonstrated that the gene content and the chromosomal arrangement among Helicobacter pylori strains are highly variable. Furthermore, this variability has been observed in different genes, such as vacA, which has a mosaic structure, and in cag-PAI, which has a different chromosomal organization. Preliminary study suggests that vapD is a strain-variable gene and it is present in about 60% of H. pylori strains. vapD gene is closely related to the virulence-associated protein D gene of Dichelobacter nodosus. The aim of this study was to characterize and to determine the frequency of vapD gene, in 301 Helicobacter pylori strains with different vacA and cag-PAI genotypes isolated from 27 Mexican patients with different gastric pathologies. The results showed that 70% of the patients presented multiple infections with H. pylori strains of different, vacA, and cag-PAI genotypes. Fifty two percent of the patients were colonized with vapD-positive and -negative strains. Regarding the vapD gene characterization by individual strains, it presented a frequency of 38%. This is the first characterization report that shows the frequency of vapD gene in H. pylori strains from Mexican patients. With respect to vacA and cag-PAI, the s1-m1/cag-PAI positive genotypes were more frequent in strains isolated from patients with recurrent abdominal pain (RAP), gastric ulcer (GU), and duodenal ulcer (DU). Statistical analysis showed that the vapD gene did not have association with any specific family of vacA or cag-PAI genotypes and specific gastric pathology. Diversos estudios, realizados con diferentes técnicas de tipificación molecular han demostrado que el contenido genético y arreglo cromosómico entre cepas de Helicobacter pylori son altamente variables. Además, se ha observado esta variabilidad en diferentes genes, como vacA que presenta una estructura de mosaico y cag-PAI, que presenta una organización diferente en el cromosoma. Un estudio preliminar sugiere que el gen vapD, es un gen variable de cepa, presente en aproximadamente 60% de las cepas de H. pylori. El gen vapD está relacionado con el gen de la proteína D asociada a virulencia de Dichelobacter nodosus. El objetivo de este estudio fue caracterizar y determinar la frecuencia del gen vapD en 301 cepas de H. pylori con diferentes genotipos de vacA y cag-PAI, provenientes de 27 pacientes con diferentes patologías gástricas. Los resultados mostraron que el 70% de los pacientes presentan infección múltiple con cepas de H. pylori de diferentes genotipos de vacA y cag-PAI. El 52% de ellos estuvieron colonizados con cepas vapD positivas y vapD negativas. La caracterización de vapD en cepas individuales, mostró una frecuencia del 38%. Este es el primer estudio que muestra la frecuencia de vapD en cepas de H. pylori aisladas de pacientes mexicanos. Con respecto a los genes vacA y cag-PAI, el genotipo más frecuente entre las cepas fue s1-m1/cag-PAI+, aisladas de pacientes con dolor abdominal crónico, úlcera gástrica y úlcera duodenal. El gen vapD no tiene asociación significativa con un alelo específico de vacA o el genotipo de cag-PAI y la patología gástrica. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: Y custom: Copyright of Revista Neurologia, Neurocirugia y Psiquiatria is the property of Sociedad Mexicana de Neurologia y Psiquiatria A.C. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. item: Revista Neurologia, Neurocirugia y Psiquiatria holder: Sociedad Mexicana de Neurologia y Psiquiatria A.C. dt: @attributes: year: 2008 holdings: @attributes: islocal: N |
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