Water disinfection by-products and the risk of specific birth defects: a population-based cross-sectional study in Taiwan.
Background: Recent findings suggest that exposure to disinfection by-products may increase the risk of birth defects. Previous studies have focused mainly on birth defects in general or groups of defects. The objective of the present study was to assess the effect of water disinfection by-products o...
| Publicado en: | Environmental Health: A Global Access Science Source Vol. 7; pp. 1 - 12 |
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| Autores principales: | , , , , , |
| Formato: | research Journal Article |
| Publicado: |
BioMed Central
2008
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=35703133&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 35703133 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 1476069X 1CNO jtl: Environmental Health: A Global Access Science Source issn: 1476069X maglogo: N pubinfo: dt: 2008 vid: 7 pid: 24147 pub: BioMed Central artinfo: ui: 35703133 35703133 NLM18518952 35703133 10.1186/1476-069X-7-23 NLM18518952 35703133 ppf: 1 ppct: 11 formats: tig: atl: Water disinfection by-products and the risk of specific birth defects: a population-based cross-sectional study in Taiwan. aug: au: Bing-Fang Hwang Jaakkola, Jouni J. K. How-Ran Guo Hwang, Bing-Fang Jaakkola, Jouni Jk Guo, How-Ran affil: Department and Graduate Institute of Occupational Safety and Health, College of Public Health, China Medical University, No.91 Hsueh-Shih Road, Taichung 40402, Taiwan, ROC sug: subj: Maternal Exposure Abnormalities Etiology Environmental Pollutants Water Supply Hydrocarbons, Halogenated Prenatal Exposure Delayed Effects Disinfectants Male Water Supply Analysis Pregnancy Environmental Exposure Risk Assessment Multivariate Analysis Female Taiwan Abnormalities Epidemiology Infant, Newborn Cross Sectional Studies Adult Human Odds Ratio Logistic Regression Risk Factors Maternal Exposure Adverse Effects Retrospective Design Comparative Studies Meta Analysis Multicenter Studies Evaluation Research Validation Studies Questionnaires Infant, Newborn: birth-1 month Adult: 19-44 years Male Female ab: Background: Recent findings suggest that exposure to disinfection by-products may increase the risk of birth defects. Previous studies have focused mainly on birth defects in general or groups of defects. The objective of the present study was to assess the effect of water disinfection by-products on the risk of most common specific birth defects.Methods: We conducted a population-based cross-sectional study of 396,049 Taiwanese births in 2001-2003 using information from the Birth Registry and Waterworks Registry. We compared the risk of eleven most common specific defects in four disinfection by-product exposure categories based on the levels of total trihalomethanes (TTHMs) representing high (TTHMs 20+ microg/L), medium (TTHMs 10-19 microg/L), low exposure (TTHMs 5-9 microg/L), and 0-4 microg/L as the reference category. In addition, we conducted a meta-analysis of the results from the present and previous studies focusing on the same birth defects.Results: In multivariate logistic regression analysis the risk of ventricular septal defects (adjusted odds ratio 1.81, 95% confidence interval: 0.98 3.35), cleft palate (1.56. 95% CI: 1.00, 2.41), and anencephalus (1.96, 95% CI: 0.94, 4.07) were elevated in the high exposure compared to the reference category. In the meta-analysis, the summary odds ratio for ventricular septal defects (1.59, 95% CI: 1.21, 2.07) was consistently elevated.Conclusion: The present study suggests that prenatal exposure to disinfection by-products increases the risk of ventricular septal defects, cleft palate, and anencephalus. The evidence on ventricular septal defects is consistent in the three available studies. pubtype: Academic Journal doctype: meta analysis research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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