Impaired oxidation of plasma-derived fatty acids in type 2 diabetic subjects during moderate-intensity exercise.
The present study was intended to investigate the different components of fatty acid utilization during a 60-min period of moderate-intensity cycling exercise (50% of VO2max) in eight male type 2 diabetic subjects (aged 52.6 +/- 3.1 years, body fat 35.8 +/- 1.3%) and eight male obese control subject...
| Publicado en: | Diabetes Vol. 49; no. 12; pp. 2102 - 2108 |
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| Autores principales: | , , , , , |
| Formato: | research Journal Article |
| Publicado: |
American Diabetes Association
Dec2000
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=3895755&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 3895755 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00121797 1G6 jtl: Diabetes issn: 00121797 maglogo: N pubinfo: dt: Dec2000 vid: 49 iid: 12 pid: 1367 pub: American Diabetes Association place: Arlington, Virginia artinfo: ui: 3895755 3895755 NLM11118013 3895755 10.2337/diabetes.49.12.2102 NLM11118013 3895755 ppf: 2102 ppct: 6 formats: tig: atl: Impaired oxidation of plasma-derived fatty acids in type 2 diabetic subjects during moderate-intensity exercise. aug: au: Blaak, Ellen E. Blaak, E E van Aggel-Leijssen, D P Wagenmakers, A J Saris, W H van Baak, M A affil: Department of Human Biology, Nutrition Research Centre, Maastricht University, The Netherlands sug: subj: Fatty Acids Metabolism Diabetes Mellitus, Type 2 Blood Exercise Oxygen Consumption Reference Values Insulin Blood Human Calorimetry Fatty Acids Blood Arteries Obesity Complications Male Diabetes Mellitus, Type 2 Complications Oxidation-Reduction Blood Glucose Analysis Middle Age Osmolar Concentration Validation Studies Comparative Studies Evaluation Research Multicenter Studies Exercise of Self-Care Agency Scale Middle Aged: 45-64 years Male ab: The present study was intended to investigate the different components of fatty acid utilization during a 60-min period of moderate-intensity cycling exercise (50% of VO2max) in eight male type 2 diabetic subjects (aged 52.6 +/- 3.1 years, body fat 35.8 +/- 1.3%) and eight male obese control subjects (aged 45.1 +/- 1.4 years, body fat 34.2 +/- 1.3%) matched for age, body composition, and maximal aerobic capacity. To quantitate the different components of fatty acid metabolism, an isotope infusion of [U-13C]-palmitate was used in combination with indirect calorimetry. In separate experiments, the 13C label recovery in expired air was determined during infusion of [1,2-13C]-acetate (acetate recovery factor). There were no differences in energy expenditure or carbohydrate and total fat oxidation between the groups. The rate of appearance (Ra) of free fatty acid (FFA) (P < 0.05) and the exercise-induced increase in Ra of FFA were significantly lower (P < 0.05) in type 2 diabetic subjects compared with control subjects (baseline vs. exercise [40-60 min]; type 2 diabetes 11.9 +/- 0.9 vs. 19.6 +/- 2.2 micromol x kg(-1) fat-free mass [FFM] x min(-1) and control 15.8 +/- 1.8 vs. 28.6 +/- 2.1 micromol x kg(-1) FFM x min(-1)). The oxidation of plasma-derived fatty acids was significantly lower in type 2 diabetic subjects during both conditions (P < 0.05, baseline vs. exercise [40-60 min]; type 2 diabetes 4.2 +/- 0.5 vs. 14.1 +/- 1.9 micromol x kg(-1) FFM x min(-1) and control 6.2 +/- 0.6 vs. 20.4 +/- 1.9 micromol x kg(-1) FFM x min(-1)), whereas the oxidation of triglyceride-derived fatty acids was higher (P < 0.05). It is hypothesized that these impairments in fatty acid utilization may play a role in the etiology of skeletal muscle and hepatic insulin resistance. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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