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Selective Recognition of Unnatural lmidazopyridopyrimidine:Naphthyridine Base Pairs Consisting of Four Hydrogen Bonds by the Klenow Fragment.

The article presents a study on the importance of selective recognition of DNA polymerases as a fundamental biological process in transmitting genetic information. It outlines the investigation on the thermal stability of ImO:Nan and ImN:NaO pairs base on the DNA polymerases and Klenow fragment (KF)...

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Published in:Journal of the American Chemical Society Vol. 131; no. 5; pp. 1644 - 1646
Main Authors: Minakawa, Noriaki, Ogata, Shintaro, Takahashi, Mayumi, Matsuda, Akira
Format: Article
Published: American Chemical Society 2/11/2009
Subjects:
DNA polymerases
Genetic code
Genetic translation
Nucleotide sequence
Transferases
Online Access:View this record in EBSCOhost
Summary:The article presents a study on the importance of selective recognition of DNA polymerases as a fundamental biological process in transmitting genetic information. It outlines the investigation on the thermal stability of ImO:Nan and ImN:NaO pairs base on the DNA polymerases and Klenow fragment (KF). It states that the result contributes towards the development of alternative stable base pairs to expand the genetic code.