Flipons : The Discovery of Z-DNA and Soft-Wired Genomes
Alan Herbert has played a leading part in discovering the biological roles for a high-energy form of DNA twisted to the left rather than to the right. Both Z-DNA and the Z-RNA sensing proteins are critical for protecting hosts against both viruses and cancers. The proteins also play critical roles i...
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CRC Press
2024
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=nlebk&AN=4000181&site=ehost-live header: @attributes: shortDbName: nlebk uiTerm: 4000181 longDbName: eBook Collection (EBSCOhost) uiTag: AN controlInfo: bkinfo: btl: Flipons : The Discovery of Z-DNA and Soft-Wired Genomes aug: au: Alan Herbert isbn: 9781032731087 9781032732961 9781040024959 9781040025000 imageinfo: pubinfo: dt: @attributes: year: 2024 month: 01 day: 01 dtAvail: @attributes: year: 2024 month: 10 day: 04 ed: First edition pub: CRC Press pubContract: CRC Press (Unlimited) place: Boca Raton, FL price: 0.01 limitsGroup: maxCheckoutDays: 1500 copyPages: -1 pda: N printPagesOffline: 60 printPagesOnline: 60 previewPages: 10000 prePubGroup: dewey: @attributes: class: 572.86 item: 572 .86 lc: @attributes: class: QH447 item: QH 447 artinfo: ui: 4000181 1428266127 formats: fmt: – @attributes: type: EB doid: NL$4000181$PDF caption: PDF download: Y – @attributes: type: EK doid: NL$4000181$EPUB caption: EPUB download: Y tig: atl: Flipons : The Discovery of Z-DNA and Soft-Wired Genomes ptl: Flipons aug: au: Alan Herbert su: Z-DNA Science sug: subj: SCIENCE / Life Sciences / Genetics & Genomics SCIENCE / Life Sciences / Biochemistry SCIENCE / Life Sciences / Molecular Biology Z-DNA Science ab: Alan Herbert has played a leading part in discovering the biological roles for a high-energy form of DNA twisted to the left rather than to the right. Both Z-DNA and the Z-RNA sensing proteins are critical for protecting hosts against both viruses and cancers. The proteins also play critical roles in the programmed cell death of aging cells. Other types of flipons exist and alter the readout of transcripts from the genome, encoding genetic information by their shape rather than by their sequence. Many of these flipons are within repeat elements that were previously considered to be just genomic junk. Instead these genetic elements increase the adaptability of cells by flipping DNA conformation. By acting as digital switches, the different flipon types can alter cellular responses without any change to their sequence or any damage to DNA. These highly dynamic structures enable the rapid evolution of multicellular organisms. The junk DNA in repeats also encode peptide patches that enable the assembly of cellular machines. The intransitive logic involved enhances the chance of an individual surviving a constantly changing environment.Key Features Causes us to rethink how information is encoded in the genome Changes our understanding of how our genome evolved and how we protect ourselves against viruses and cancers while sparing normal cells Shows that high energy forms of DNA, such as left-handed DNA do exist inside the cell Accessible to those in academia and the general public, and speaks to the next generation, encouraging them to find their own path in scientific discovery The Open Access version of this book, available at http://www.taylorfrancis.com, has been made available under a Creative Commons Attribution-Non-Commercial-No Derivative License (CC-BY-NC-ND) 4.0 license. pubtype: eBook doctype: Book ougenre: Book language: English copyright: @attributes: flag: N copyrightText: holdings: @attributes: islocal: N |
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