Structure of a Nickel Chaperone, HypA, from Helicobacter pylon Reveals Two Distinct Metal Binding Sites.

Metaltochaperones bind metals and ensure the safe delivery of metals to the targets. They are required for the activation and maturation of nickel-containing enzymes [Ni,Fe]-hydrogenase and urease. Metallochaperone HypA was found to be essential to facilitate nickel delivery to hydrogenase together...

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Bibliographic Details

Published in:	Journal of the American Chemical Society Vol. 131; no. 29; pp. 10031 - 10041
Main Authors:	Xia, Wei, Li, Hongyan, Sze, Kong-Hung, Sun, Hongzhe
Format:	Article
Published:	American Chemical Society 7/29/2009
Subjects:	Molecular chaperones Nickel compounds Metal bonding Binding sites Helicobacter pylori Zinc compounds Nuclear magnetic resonance spectroscopy Cysteine proteinases
Online Access:	View this record in EBSCOhost