Mechanistic Study of the sPLA-Mediated Hydrolysis of a Thio-ester Pro Anticancer Ether Lipid.

Secretory phospholipase A (sPLA) is an interesting enzyme for triggered liposomal drug delivery to tumor tissue due the overexpression of sPLA in cancerous tissue. A drug delivery system based on the triggered release of therapeutics from sPLA-sensitive liposomes constituted of pro anticancer ether...

Descripción completa

Detalles Bibliográficos

Publicado en:	Journal of the American Chemical Society Vol. 131; no. 34; pp. 12193 - 12201
Autores principales:	Linderoth, Lars, Fristrup, Peter, Hansen, Martin, Melander, Fredrik, Madsen, Robert, Andresen, Thomas L., Peters, Günther H.
Formato:	Artículo
Publicado:	American Chemical Society 9/2/2009
Materias:	Density functionals Hydrolysis Phospholipids Liposomes Cytoplasm Ethers
Acceso en línea:	Ver este registro en EBSCOhost