Helicobacter pylori-negative gastric and duodenal ulcers.
It is unclear whether Helicobacter pylori infection is essential to the development of peptic ulcers. In this study, we examined the rates of H. pylori-negativity among patients with peptic ulcers. We also attempted to clarify the characteristics of H. pylori-negative peptic ulcers to throw light on...
| Publicado en: | Journal of Gastroenterology Vol. 34; no. 4; pp. 455 - 461 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
1999
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=4689956&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 4689956 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09441174 EJ7 jtl: Journal of Gastroenterology issn: 09441174 maglogo: N pubinfo: dt: 1999 vid: 34 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 4689956 4689956 NLM10452677 4689956 10.1007/s005350050296 NLM10452677 4689956 ppf: 455 ppct: 6 formats: tig: atl: Helicobacter pylori-negative gastric and duodenal ulcers. aug: au: Tsuji, Hideharu Kohli, Yoshihiro Fukumitsu, Shinji Morita, Kiyoshi Kaneko, Hiroto Ohkawara, Tohru Minami, Masahito Ueda, Kazushige Sawa, Yoshihiko Matsuzaki, Haruki Morinaga, Osamu Ohkawara, Yasuo Tsuji, H Kohli, Y Fukumitsu, S Morita, K Kaneko, H Ohkawara, T Minami, M Ueda, K affil: Department of Internal Medicine, Aiseikai Yamashina Hospital, Kyoto, Japan sug: subj: Helicobacter Pylori Peptic Ulcer Microbiology Duodenal Ulcer Microbiology Duodenal Ulcer Pathology Middle Age Gastric Mucosa Microbiology Endoscopy, Gastrointestinal Aged, 80 and Over Incidence Aged Peptic Ulcer Pathology Gastric Mucosa Pathology Helicobacter Infections Epidemiology Peptic Ulcer Epidemiology Female Male Duodenal Ulcer Epidemiology Adult Biopsy Human Middle Aged: 45-64 years Aged, 80 & over Aged: 65+ years Adult: 19-44 years Female Male ab: It is unclear whether Helicobacter pylori infection is essential to the development of peptic ulcers. In this study, we examined the rates of H. pylori-negativity among patients with peptic ulcers. We also attempted to clarify the characteristics of H. pylori-negative peptic ulcers to throw light on the pathogenesis of peptic ulcers. The study included 215 consecutive patients with gastric ulcers (GUs) and 120 consecutive patients with duodenal ulcers (DUs). After routine endoscopic examination and phenol red dye endoscopy, forceps biopsies were performed for culture, histology, and the rapid urease test. A patient was considered H. pylori-negative when the serum anti-H. pylori IgG and the three tests on biopsied specimens were all negative. H. pylori-negative rates were 3.2% in the patients with GUs and 1.7% in the patients with DUs. Lack of atrophy of the gastric mucosa was significantly more common in the H. pylori-negative patients with GUs. A history of ulcer disease was less common and antral ulcers were more common in H. pylori-negative GU patients, but not significantly so. As the urea breath test had not been performed, the possibility of a false-negative result cannot be completely ruled out, but we believe that the H. pylori-negative rate in our study is more reliable than these rates in previous reports, because we visualized H. pylori distribution by phenol red dye endoscopy to avoid false-negative results in biopsies, and we used both biopsy and serum anti-H. pylori IgG findings to establish an H. pylori-negative diagnosis. Since H. pylori-negative peptic ulcers certainly exist, H. pylori infection is thought not to be essential to the development of peptic ulcers. There were few differences between the characteristics of H. pylori-negative and H. pylori-positive peptic ulcers in our study. A large-scale study is required to clarify the characteristics of H. pylori-negative peptic ulcers. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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