Pyoderma gangrenosum complicating ulcerative colitis: Successful treatment with methylprednisolone pulse therapy and cyclosporine.

A 32-year-old woman with ulcerative colitis had a relapsed of pyoderma gangrenosum during puerperium. Both the pyoderma gangrenosum and ulcerative colitis had been well controlled with oral prednisolone, but ulcerative colitis relapsed in pregnancy, and pyoderma gangrenosum relapsed in the puerperiu...

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Published in:Journal of Gastroenterology Vol. 33; no. 3; pp. 408 - 412
Main Authors: Futami, Hajime, Kodaira, Makoto, Furuta, Takahisa, Hanai, Hiroyuki, Kaneko, Eizo, Futami, H, Kodaira, M, Furuta, T, Hanai, H, Kaneko, E
Format: case study Journal Article
Published: Springer Nature 1998
Online Access:View this record in EBSCOhost
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      dt: 1998
      vid: 33
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      pub: Springer Nature
      place: New York, New York
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        atl: Pyoderma gangrenosum complicating ulcerative colitis: Successful treatment with methylprednisolone pulse therapy and cyclosporine.
      aug:
        au:
          Futami, Hajime
          Kodaira, Makoto
          Furuta, Takahisa
          Hanai, Hiroyuki
          Kaneko, Eizo
          Futami, H
          Kodaira, M
          Furuta, T
          Hanai, H
          Kaneko, E
        affil: First Department of Medicine, Hamamatsu University of Medicine, Japan
      sug:
        subj:
          Pyoderma Gangrenosum Drug Therapy
          Antiinflammatory Agents Therapeutic Use
          Immunosuppressive Agents Therapeutic Use
          Colitis, Ulcerative Drug Therapy
          Methylprednisolone Therapeutic Use
          Cyclosporine Therapeutic Use
          Facial Dermatoses Drug Therapy
          Pregnancy Complications
          Drug Therapy, Combination
          Facial Dermatoses Complications
          Female
          Pyoderma Gangrenosum Complications
          Pregnancy
          Pyoderma Gangrenosum Pathology
          Colitis, Ulcerative Complications
          Adult
          Antiinflammatory Agents Administration and Dosage
          Methylprednisolone Administration and Dosage
          Colitis, Ulcerative Pathology
          Adult: 19-44 years
          Female
      ab: A 32-year-old woman with ulcerative colitis had a relapsed of pyoderma gangrenosum during puerperium. Both the pyoderma gangrenosum and ulcerative colitis had been well controlled with oral prednisolone, but ulcerative colitis relapsed in pregnancy, and pyoderma gangrenosum relapsed in the puerperium. The pyoderma gangrenosum responded to methylprednisolone pulse therapy initially, but relapsed when prednisolone was tapered. A second trial of pulse therapy combined with cyclosporine resulted in complete remission of the pyoderma gangrenosum, and no recurrence was recognized after prednisolone was tapered. This is a very rare case of successful treatment with methylprednisolone pulse therapy combined with cyclosporine for pyoderma gangrenosum complicating ulcerative colitis.
      pubtype: Academic Journal
      doctype:
        case study
        Journal Article
      ougenre: Article
    language: English
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