Quantification of Helicobacter pylori infection: Simple and rapid 13C-urea breath test in Taiwan.
The 13C-urea breath test (13C-UBT) is a non-invasive method for detecting Helicobacter pylori. This study was performed to determine the cutoff value and evaluate the sensitivity and specificity of 13C-UBT in Taiwan. 13C-Urea (100 mg of 99% 13C-labeled urea) was dissolved in 50 ml sterile water for...
| Publicado en: | Journal of Gastroenterology Vol. 33; no. 3; pp. 330 - 336 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
1998
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=4690201&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 4690201 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09441174 EJ7 jtl: Journal of Gastroenterology issn: 09441174 maglogo: N pubinfo: dt: 1998 vid: 33 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 4690201 4690201 NLM9658310 4690201 10.1007/s005350050092 NLM9658310 4690201 ppf: 330 ppct: 6 formats: tig: atl: Quantification of Helicobacter pylori infection: Simple and rapid 13C-urea breath test in Taiwan. aug: au: Wang, Wen-Ming Lee, Shui-Cheng Ding, Hueisch-Jy Jan, Chang-Ming Chen, Li-Tzong Wu, Deng-Chyang Liu, Chiang-Shin Peng, Chien-Fang Chen, Yu-Wen Huang, Ying-Fong Chen, Chang-Yi Wang, W M Lee, S C Ding, H J Jan, C M Chen, L T Wu, D C Liu, C S Peng, C F Chen, Y W affil: Department of Internal Medicine, Kaohsiung Medical College, Taiwan, ROC sug: subj: Gastrointestinal Diseases Diagnosis Urea Metabolism Helicobacter Pylori Breath Tests Methods Helicobacter Infections Diagnosis Aged Taiwan Middle Age Aged, 80 and Over Adult Helicobacter Infections Microbiology Male Female Isotopes Gastrointestinal Diseases Microbiology Adolescence Sensitivity and Specificity Human Endoscopy, Gastrointestinal Validation Studies Comparative Studies Evaluation Research Multicenter Studies Scales Aged: 65+ years Middle Aged: 45-64 years Aged, 80 & over Adult: 19-44 years Adolescent: 13-18 years Male Female ab: The 13C-urea breath test (13C-UBT) is a non-invasive method for detecting Helicobacter pylori. This study was performed to determine the cutoff value and evaluate the sensitivity and specificity of 13C-UBT in Taiwan. 13C-Urea (100 mg of 99% 13C-labeled urea) was dissolved in 50 ml sterile water for the test. The test meal for delaying gastric emptying was 100 ml fresh milk. Patients fasted for at least 6h. A baseline breath sample was collected 5 min after they had the test meal. Two other samples were collected at 15 and 30 min after the patients ingested the 13C-urea. The test was evaluated in 352 patients after routine upper gastrointestinal endoscopy, and the urease test, culture, and histopathology were taken as the gold standards for detecting H. pylori. According to the receiver operating characteristic (ROC) curves, we chose values of 2.8 and 4.2 excess delta 13CO2 per mil as the cut-off values for 15 and 30 min, respectively, post 13C-urea. The sensitivity and specificity of 13C-UBT were 99% and 93% at 15 min, and 98% and 93% at 30 min post 13C-urea, respectively. The 13C-UBT breath test is an efficient non-invasive method of high sensitivity and high specificity for detecting H. pylori infection. We suggest that the use of fresh milk as the test meal and the detection of excess delta 13CO2 15 min after the ingestion of 13C-urea are suitable for the clinical use of 13C-UBT. This test is simple and rapid. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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