New Insights into the Vacuum UV Photodissociation of Peptides.
Vacuum ultraviolet laser photodissociation (UVPD) of peptide ions leads to unusual dissociation channels involving backbone C-C bond breaking. However, the molecular basis for the observed behavior is not clearly understood. We now report theoretical investigations using ab initio/density functional...
| Publicado en: | Journal of the American Chemical Society Vol. 132; no. 5; pp. 1606 - 1611 |
|---|---|
| Autores principales: | , , , |
| Formato: | Artículo |
| Publicado: |
American Chemical Society
2/10/2010
|
| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=hlh&AN=48375907&site=ehost-live header: @attributes: shortDbName: hlh uiTerm: 48375907 longDbName: Humanities International Complete uiTag: AN controlInfo: bkinfo: jinfo: jid: 00027863 ACS jtl: Journal of the American Chemical Society issn: 00027863 maglogo: N pubinfo: dt: 2/10/2010 vid: 132 iid: 5 pid: 997 pub: American Chemical Society artinfo: ui: 48375907 10.1021/ja907975v ppf: 1606 ppct: 5 formats: tig: atl: New Insights into the Vacuum UV Photodissociation of Peptides. aug: au: Parthasarathi, Ramakrishnan Yi He Reilly, James P. Raghavachari, Krishnan affil: Department of Chemistry, Indiana University, Bloomington, Indiana 47405, USA su: Far ultraviolet radiation Peptides Photodissociation Density functionals Fragmentation reactions sug: subj: Far ultraviolet radiation Peptides Photodissociation Density functionals Fragmentation reactions ab: Vacuum ultraviolet laser photodissociation (UVPD) of peptide ions leads to unusual dissociation channels involving backbone C-C bond breaking. However, the molecular basis for the observed behavior is not clearly understood. We now report theoretical investigations using ab initio/density functional theory (DFT) techniques on neutral and protonated dipeptides undergoing vacuum ultraviolet (VUV) induced fragmentation via a Rydberg excitation (and/or electron detachment) and subsequent C-C bond cleavage. New experimental results on VUV photodissociation of dipeptides (protonated Ala̱Arg and Arg̱Ala) provide strong support for our proposed model. Our mechanism also provides a natural explanation for the presence of immonium ions that are sometimes observed in such experiments. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: Y dt: @attributes: year: 2010 holdings: @attributes: islocal: N |
|---|