The Importance of Hydrogen Bonding between the Glutamine Side Chains to the Formation of Amyloid VOIVYK Parallel β-Sheets: An ONIOM DFT/AM1 Study.
The article presents an analysis on hydrogen bonding among glutamine side chains which forms the amyloid parallel β-sheets fibrils from the six amino acid sequences, VQIVYK. It states that calculations of molecular orbital (MO) with the GAUSSIAN 03 and GAUSSIAN 09 computer programs were made using o...
| Publicado en: | Journal of the American Chemical Society Vol. 132; no. 6; pp. 1758 - 1760 |
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| Autores principales: | , |
| Formato: | Artículo |
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American Chemical Society
2/17/2010
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=hlh&AN=48404844&site=ehost-live header: @attributes: shortDbName: hlh uiTerm: 48404844 longDbName: Humanities International Complete uiTag: AN controlInfo: bkinfo: jinfo: jid: 00027863 ACS jtl: Journal of the American Chemical Society issn: 00027863 maglogo: N pubinfo: dt: 2/17/2010 vid: 132 iid: 6 pid: 997 pub: American Chemical Society artinfo: ui: 48404844 10.1021/ja909690a ppf: 1758 ppct: 2 formats: tig: atl: The Importance of Hydrogen Bonding between the Glutamine Side Chains to the Formation of Amyloid VOIVYK Parallel β-Sheets: An ONIOM DFT/AM1 Study. aug: au: Plumley, Joshua A. Dannenberg, J. J. affil: Department of Chemistry, Hunter College and the Graduate School, City University of New York, 695 Park A venue, New York, New York 10065 su: Hydrogen bonding Amyloid beta-protein Glutamine Amino acid sequence Computer software Molecular orbitals Gaussian measures sug: subj: Hydrogen bonding Amyloid beta-protein Glutamine Amino acid sequence Computer software Molecular orbitals Gaussian measures ab: The article presents an analysis on hydrogen bonding among glutamine side chains which forms the amyloid parallel β-sheets fibrils from the six amino acid sequences, VQIVYK. It states that calculations of molecular orbital (MO) with the GAUSSIAN 03 and GAUSSIAN 09 computer programs were made using our own n-layered Integrated molecular orbital + molecular mechanics (ONIOM) method with MO and Austin Model 1 (AM1) methods. It concludes that H-bonds contribute to the formation of amyloid. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: Y dt: @attributes: year: 2010 holdings: @attributes: islocal: N |
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