Origins of Regioselectivity and Alkene-Directing Eftects in Nickel-Catalyzed Reductive Couplings of Alkynes and Aldehydes.

The origins of reactivity and regioselectivity in nickel-catalyzed reductive coupling reactions of alkynes and aldehydes were investigated with density functional calculations. The regioselectivities of reactions of simple alkynes are controlled by steric effects, while conjugated enynes and diynes...

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Bibliographic Details

Published in:	Journal of the American Chemical Society Vol. 132; no. 6; pp. 2050 - 2058
Main Authors:	Peng Liu, McCarren, Patrick, Ha-Yeon Cheong, Paul, Jamison, Timothy F., Houk, K. N.
Format:	Article
Published:	American Chemical Society 2/17/2010
Subjects:	Reactivity (Chemistry) Nickel catalysts Alkynes Aldehydes Density functionals
Online Access:	View this record in EBSCOhost