VARIABILIDAD DEL PATRON RESPIRATORIO DURANTE LA CARGA ELASTICA INSPIRATORIA.
In humans, lung ventilation exhibits breath-to-breath variability and dynamics that are nonlinear, complex and chaotic. Our objective was to characterize the breathing pattern variational activity in anesthetized dogs (n: 8) breathing through threshold inspiratory elastic load (7 to 50 cm H2O). Star...
| Publicado en: | Medicina (Buenos Aires) Vol. 69; no. 3; pp. 311 - 318 |
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| Autores principales: | , , |
| Formato: | Artículo |
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Medicina (Buenos Aires)
2009
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=lth&AN=48922094&site=ehost-live header: @attributes: shortDbName: lth uiTerm: 48922094 longDbName: MedicLatina uiTag: AN controlInfo: bkinfo: jinfo: jid: 00257680 50C2 jtl: Medicina (Buenos Aires) issn: 00257680 maglogo: N pubinfo: dt: 2009 vid: 69 iid: 3 pid: 39353 pub: Medicina (Buenos Aires) artinfo: ui: 48922094 ppf: 311 ppct: 7 formats: fmt: @attributes: type: P size: 111KB tig: atl: VARIABILIDAD DEL PATRON RESPIRATORIO DURANTE LA CARGA ELASTICA INSPIRATORIA. aug: au: D'Negri, Carlos E. Pessolano, Fernando A. De Vito, Eduardo L. affil: Instituto de Investigaciones Médicas Alfredo Lanari, Facultad de Medicina, Universidad de Buenos Aires su: Respiratory measurements Pulmonary function tests Esophageal motility Mechanical ventilators Respiratory therapy equipment Anesthetics Pharmacodynamics sug: subj: Respiratory measurements Pulmonary function tests Esophageal motility Mechanical ventilators Respiratory therapy equipment Anesthetics Pharmacodynamics keyword: breathing pattern breathing variability complexity analysis control of breathing elastic load Fourier transform nonlinear analysis análisis de complejidad análisis no lineal carga elástica control de la respiración patrón respiratorio transformada de Fourier ab: In humans, lung ventilation exhibits breath-to-breath variability and dynamics that are nonlinear, complex and chaotic. Our objective was to characterize the breathing pattern variational activity in anesthetized dogs (n: 8) breathing through threshold inspiratory elastic load (7 to 50 cm H2O). Starting from flow signal and tracheal and esophageal pressures, we analyzed inspiratory time (Ti), timing (expiratory time, Te; total time, Ttot; and Ti/Ttot) and central drive (Vt/Ti) and variables related to it (tidal volume, Vt and pulmonary ventilation, Ve). We measured gross variability (variances), low frequency oscillations (spectral analysis), and short term memory (autocorrelation analysis). Loading decreased variance of the mean values of Te, Ttot, Vt and Vt/Ti (p < 0.05); the mean of variances for Ti/Ttot increased (p < 0.005) while it decreased for Vt and Vt/Ti (p < 0.05). In general, percent of data recordings with low frequency oscillations (OB%) decreased (p < 0.02). During heavy load, timing parameters percent of data recordings with autocorrelations (AU%) did not change, but Vt and its related parameters decreased their AU% (p < 0.005). There was a positive correlation (r: 0.955, p < 0.001) between the existence of low frequency oscillations and autocorrelations for Vt and its related parameters, while timing variables did not show such a correlation. In conclusion, threshold elastic load induced a monotonous respiratory pattern. The short term memory decreased during inspiratory stage while increased during expiratory stage. These changes occurred during anesthesia suggesting that certain suprapontine structures may not be obligatory to induce them. La ventilación pulmonar en humanos tiene una variabilidad respiración a respiración no lineal, compleja y caótica. El objetivo del trabajo fue: caracterizar la variabilidad del patrón respiratorio en perros (n: 8) anestesiados respirando bajo carga elástica umbral (CEU) inspiratoria (7 a 50 cm H2O). Con el flujo, presión traqueal y esofágica, se analizaron: tiempo inspiratorio (Ti), ritmo [tiempo espiratorio (Te); tiempo total (Ttot), y Ti/Ttot] e impulso central (Vt/Ti), variables relacionadas [volumen corriente (Vt) y ventilación pulmonar (Ve)]. Se determinaron: variabilidad grosera (varianzas), oscilaciones de baja frecuencia (análisis espectral) y memoria a corto plazo (análisis de autocorrelación). La CEU produjo disminución de la varianza de medias en Te, Ttot, Vt y Vt/Ti (p < 0.05). La media de las varianzas del Ti/Ttot aumentó (p < 0.005) y disminuyó para el Vt y el Vt/Ti (p < 0.05). En general, el porcentaje de oscilaciones de baja frecuencia (OB%) disminuyó (p < 0.02). Durante CEU alta, las variables de ritmo no cambiaron el porcentaje de registros con autocorrelación (AU%), pero el Vt y variables relacionadas disminuyeron los AU% (p < 0.005). Hubo correlación positiva (r: 0.955, p < 0.001) entre OB% y AU% en Vt y variables relacionadas, pero las variables de ritmo no mostraron correlación. En conclusión: La CEU indujo un patrón respiratorio más monótono. La memoria a corto plazo disminuyó en la fase inspiratoria y aumentó en la espiratoria. Estos cambios ocurrieron bajo anestesia, sugiriendo que ciertas estructuras suprapontinas pueden no ser imprescindibles para la generación de estos cambios. pubtype: Academic Journal doctype: Article src: R language: Spanish refInfo: copyright: @attributes: flag: Y custom: Copyright of Medicina (Buenos Aires) is the property of Medicina (Buenos Aires) and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. item: Medicina (Buenos Aires) holder: Medicina (Buenos Aires) dt: @attributes: year: 2009 holdings: @attributes: islocal: N |
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