Adverse drug reactions in internal medicine units at a university hospital: A descriptive pilot study.
Introduction: Adverse drug reactions (ADRs) are an important cause of morbidity and mortality among hospitalized patients. Objectives: This study was designed to describe the frequency, severity, and causality of ADRs in internal medicine units at a third-level university hospital. Materials and met...
| Published in: | Colombia Medica Vol. 41; no. 1; pp. 41.45 - 48.45 |
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| Main Authors: | , , , , |
| Format: | Article |
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Universidad del Valle
ene-mar2010
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=lth&AN=49735079&site=ehost-live header: @attributes: shortDbName: lth uiTerm: 49735079 longDbName: MedicLatina uiTag: AN controlInfo: bkinfo: jinfo: jid: 01208322 165D jtl: Colombia Medica issn: 01208322 maglogo: N pubinfo: dt: ene-mar2010 vid: 41 iid: 1 pid: 19876 pub: Universidad del Valle artinfo: ui: 49735079 10.25100/cm.v41i1.684 ppf: 41.45 ppct: 7 formats: fmt: @attributes: type: P size: 111KB tig: atl: Adverse drug reactions in internal medicine units at a university hospital: A descriptive pilot study. aug: au: LÓPEZ, LUIS CARLOS BOTERO, MARCELA PINO, JAIME RAMÍREZ, JORGE HERNÁN PALACIOS, MAURICIO affil: School of Medicine, Universidad del Valle, Cali, Colombia. Director Programa de Medicina, Facultad de Ciencias de la Salud, Universidad Icesi, Cali, Colombia. Assistant Professor, Department of Physiological Sciences, School of Medicine, Universidad del Valle, Cali, Colombia. su: Reporting of drug side effects Hospital care evaluation Drug utilization Prevention of drug side effects Hospital wards Management sug: subj: Reporting of drug side effects Hospital care evaluation Drug utilization Prevention of drug side effects Hospital wards Management keyword: Adverse drug reactions Hospitalized patients Pharmacological surveillance Farmacovigilancia Pacientes hospitalizados Reacciones adversas a medicamentos ab: Introduction: Adverse drug reactions (ADRs) are an important cause of morbidity and mortality among hospitalized patients. Objectives: This study was designed to describe the frequency, severity, and causality of ADRs in internal medicine units at a third-level university hospital. Materials and methods: A descriptive study was performed at internal medicine units, by means of a structured format, review of clinical records, and interview of hospitalized patients. The Naranjo algorithm was applied to patient adverse events to define causality. Additionally, ADRs were classified according to the Rawlins and Thompson criteria. Results: One hundred patients (50 men and 50 women) were included in the study. Ninety nine (99) adverse events were found among the patients. The Naranjo algorithm was applied to adverse events, resulting in twenty nine (29) probable ADRs, twenty (20) possible ADRs and fifty (50) doubtful ADRs. Cardiovascular drugs and antibiotics were the most frequent therapeutic groups associated with ADRs. In addition, two preventable medication errors were identified. Conclusions: Frequency of ADRs was similar to the number reported in other studies in internal medicine units. It is necessary to systematize efforts of pharmacological surveillance in hospital wards, toward an opportune detection and prevention of ADRs. Introducción: Las reacciones adversas a medicamentos (RAM) son una importante causa de morbilidad y mortalidad en pacientes hospitalizados. Objetivos: Este estudio se diseñó para describir la frecuencia, severidad y causalidad de las RAM en las salas de Medicina Interna de un hospital universitario de tercer nivel. Materiales y métodos: Se realizó un estudio descriptivo en las salas de hospitalización de Medicina Interna, con un formato estructurado, revisión de historia clínica y entrevista a los pacientes. Para definir causalidad, se aplicó el algoritmo de Naranjo a los eventos adversos de los enfermos. Además, se clasificaron las RAM de acuerdo con los criterios de Rawlins y Thompson. Resultados: En el estudio se incluyeron 100 pacientes (50 hombres y 50 mujeres). Se informaron 99 sucesos adversos; con el algoritmo de Naranjo se clasificaron como RAM probables (n=29), RAM posibles (n=21) y RAM dudosos (n=49). Los medicamentos cardiovasculares y los antibióticos fueron los grupos terapéuticos más relacionados con efectos adversos. Se descubrieron dos errores de medicación prevenibles. Conclusiones: La frecuencia que se encontró de estas reacciones adversas fue similar a la que informaron otras investigaciones en servicios de Medicina Interna. Es necesario sistematizar los esfuerzos de fármaco-vigilancia hospitalaria para prevenir y evitar oportunamente las RAM. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: Y custom: Copyright of Colombia Medica is the property of Universidad del Valle and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. item: Colombia Medica holder: Universidad del Valle dt: @attributes: year: 2010 holdings: @attributes: islocal: N |
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