Dissociating entorhinal and hippocampal involvement in latent inhibition.
This study used anatomical cues to suggest a functional dissociation between the roles of the entorhinal cortex and the hippocampus in learning. The authors proposed that the highly convergent inputs to the entorhinal cortex indicate this region may be particularly important for selecting or compre...
| Publicado en: | Behavioral Neuroscience Vol. 114; no. 5; pp. 867 - 875 |
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| Autores principales: | , , |
| Formato: | Artículo |
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American Psychological Association
October 2000
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=506284572&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 506284572 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 07357044 BEN jtl: Behavioral Neuroscience issn: 07357044 maglogo: N pubinfo: dt: October 2000 vid: 114 iid: 5 pid: 34 pub: American Psychological Association artinfo: ui: 506284572 10.1037/0735-7044.114.5.867 ppf: 867 ppct: 8 formats: tig: atl: Dissociating entorhinal and hippocampal involvement in latent inhibition. aug: au: Shohamy, Daphna Allen, M. Todd Gluck, Mark A. su: Laboratory rabbits Hippocampus (Brain) Brain function localization Entorhinal cortex Response inhibition Paired associate learning sug: subj: Laboratory rabbits Hippocampus (Brain) Brain function localization Entorhinal cortex Response inhibition Paired associate learning keyword: Latent inhibition ab: This study used anatomical cues to suggest a functional dissociation between the roles of the entorhinal cortex and the hippocampus in learning. The authors proposed that the highly convergent inputs to the entorhinal cortex indicate this region may be particularly important for selecting or compressing information. This hypothesis was tested in rabbits (Oryctolagus cunniculus) trained on an associative learning task that is a common index of stimulus selection. In this task, known as latent inhibition preexposure to a stimulus (such as a tone) leads to slowed learning when the same tone is subsequently paired with an outcome (such as an airpuff to the eye). As hypothesized, rabbits with neurotoxic lesions of the entorhinal cortex failed to show slowed learning following preexposure (no latent inhibition) and learned the association faster than control rabbits. In contrast, hippocampal-lesioned animals showed normal (slowed) learning. Reprinted by permission of the publisher. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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