Differential sensitivity to the wake-promoting actions of norepinephrine within the medial preoptic area and the substantia innominata.
Mapping studies were conducted to delineate the site(s) of action of the arousal-enhancing actions of norepinephrine (NE) within the basal forebrain region encompassing the medial preoptic area (MPOA) and the substantia innominata (SI). Varying doses of NE, the β-agonist, isoproterenol, or the α1-a...
| Publicado en: | Behavioral Neuroscience Vol. 115; no. 1; pp. 165 - 175 |
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| Autores principales: | , |
| Formato: | Artículo |
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American Psychological Association
February 2001
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=506329575&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 506329575 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 07357044 BEN jtl: Behavioral Neuroscience issn: 07357044 maglogo: N pubinfo: dt: February 2001 vid: 115 iid: 1 pid: 34 pub: American Psychological Association artinfo: ui: 506329575 10.1037/0735-7044.115.1.165 ppf: 165 ppct: 10 formats: tig: atl: Differential sensitivity to the wake-promoting actions of norepinephrine within the medial preoptic area and the substantia innominata. aug: au: Berridge, Craig W. O'Neil, John su: Laboratory rats Brain function localization Noradrenaline Sleep-wake cycle sug: subj: Laboratory rats Brain function localization Noradrenaline Sleep-wake cycle ab: Mapping studies were conducted to delineate the site(s) of action of the arousal-enhancing actions of norepinephrine (NE) within the basal forebrain region encompassing the medial preoptic area (MPOA) and the substantia innominata (SI). Varying doses of NE, the β-agonist, isoproterenol, or the α1-agonist, phenylephrine, were infused into the MPOA or SI in the resting rat. Infusions of NE (4 nmol, 16 nmol/150 nl), isoproterenol (15 nmol/150 nl), and phenylephrine (40 nmol/250 nl) into the MPOA elicited robust increases in waking. In contrast, neither isoproterenol or phenylephrine infusions into the SI altered behavioral state. NE infusions into the SI increased waking only at the highest dose, and at this does there was an anatomical gradient for NE-induced waking, with infusions placed farther from the MPOA, producing smaller increases in waking. Thus, in contrast to the MPOA, the SI is relatively insensitive to the wake-promoting actions of NE. Reprinted by permission of the publisher. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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