Recovery of associative function following early amygdala lesions in rats.
Adult rats with amygdala lesions made at either Postnatal Day (PND) 10 or PND40 were tested on a series of reversal tasks that tap the ability to form stimulus–reward associations. PND40 rats were significantly impaired relative to both controls and PND10 rats on learning rate of the original discr...
| Publicado en: | Behavioral Neuroscience Vol. 115; no. 1; pp. 154 - 165 |
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| Autores principales: | , , |
| Formato: | Artículo |
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American Psychological Association
February 2001
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=506329579&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 506329579 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 07357044 BEN jtl: Behavioral Neuroscience issn: 07357044 maglogo: N pubinfo: dt: February 2001 vid: 115 iid: 1 pid: 34 pub: American Psychological Association artinfo: ui: 506329579 10.1037/0735-7044.115.1.154 ppf: 154 ppct: 11 formats: tig: atl: Recovery of associative function following early amygdala lesions in rats. aug: au: Higley, M. J. Hermer-Vazquez, L. Levitsky, D. A. su: Laboratory rats Amygdaloid body Discrimination learning Brain function localization sug: subj: Laboratory rats Amygdaloid body Discrimination learning Brain function localization ab: Adult rats with amygdala lesions made at either Postnatal Day (PND) 10 or PND40 were tested on a series of reversal tasks that tap the ability to form stimulus–reward associations. PND40 rats were significantly impaired relative to both controls and PND10 rats on learning rate of the original discrimination and subsequent reversals. Analyses of discrete learning phases revealed that the impairment was specific to the postchance phase. The PND10 group was not impaired relative to controls on any measure. These results confirm prior findings that amygdala lesions sustained in adulthood impair the formation of stimulus–reward associations. They also demonstrate that substantial sparing or recovery of function is possible when the lesion is made during early development. Furthermore, the findings support the view that behavioral recovery may be more likely if the lesion is sustained near the time of peak synaptogenesis. Reprinted by permission of the publisher. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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