Functional disconnection of a prefrontal cortical-dorsal striatal system disrupts choice reaction time performance: implications for attentional function.
This series of experiments investigated the role of a prefrontal cortical–dorsal striatal circuit in attention, using a continuous performance task of sustained and spatially divided visual attention. A unilateral excitotoxic lesion of the medial prefrontal cortex and a contralateral lesion of the m...
| Publicado en: | Behavioral Neuroscience Vol. 115; no. 4; pp. 812 - 826 |
|---|---|
| Autores principales: | , , |
| Formato: | Artículo |
| Publicado: |
American Psychological Association
August 2001
|
| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=506392472&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 506392472 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 07357044 BEN jtl: Behavioral Neuroscience issn: 07357044 maglogo: N pubinfo: dt: August 2001 vid: 115 iid: 4 pid: 34 pub: American Psychological Association artinfo: ui: 506392472 10.1037/0735-7044.115.4.812 ppf: 812 ppct: 14 formats: tig: atl: Functional disconnection of a prefrontal cortical-dorsal striatal system disrupts choice reaction time performance: implications for attentional function. aug: au: Christakou, Anastasia Robbins, Trevor W. Everitt, Barry J. su: Brain function localization Reaction time Laboratory rats Attention sug: subj: Brain function localization Reaction time Laboratory rats Attention ab: This series of experiments investigated the role of a prefrontal cortical–dorsal striatal circuit in attention, using a continuous performance task of sustained and spatially divided visual attention. A unilateral excitotoxic lesion of the medial prefrontal cortex and a contralateral lesion of the medial caudate–putamen were used to “disconnect” the circuit. Control groups of rats with unilateral lesions of either structure were tested in the same task. Behavioral controls included testing the effects of the disconnection lesion on Pavlovian discriminated approach behavior. The disconnection lesion produced a significant reduction in the accuracy of performance in the attentional task but did not impair Pavlovian approach behavior or affect locomotor or motivational variables, providing evidence for the involvement of this medial prefrontal corticostriatal system in aspects of visual attentional function. Reprinted by permission of the publisher. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
|---|