Selective Lesioning of the Cholinergic Septo-Hippocampal Pathway Does Not Disrupt Spatial Short-Term Memory: A Comparison With the Effects of Fimbria-Fornix Lesions.
Rats receiving intrahippocampal injections of 192 IgG-saporin (SAP-HPC), fimbria-fornix lesions (FF), or sham control surgeries were tested in a series of delayed matching (DMTP)- and nonmatching (DNMTP)-to-position tasks. The FF group was significantly impaired on a pretrained DNMTP task relative t...
| Publicado en: | Behavioral Neuroscience Vol. 118; no. 3; pp. 546 - 563 |
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| Autores principales: | , |
| Formato: | Artículo |
| Publicado: |
American Psychological Association
June 2004
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=506453268&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 506453268 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 07357044 BEN jtl: Behavioral Neuroscience issn: 07357044 maglogo: N pubinfo: dt: June 2004 vid: 118 iid: 3 pid: 34 pub: American Psychological Association artinfo: ui: 506453268 10.1037/0735-7044.118.3.546 ppf: 546 ppct: 17 formats: tig: atl: Selective Lesioning of the Cholinergic Septo-Hippocampal Pathway Does Not Disrupt Spatial Short-Term Memory: A Comparison With the Effects of Fimbria-Fornix Lesions. aug: au: Winters, Boyer D. Dunnett, Stephen B. su: Animal memory Laboratory rats Brain function localization Cholinergic mechanisms sug: subj: Animal memory Laboratory rats Brain function localization Cholinergic mechanisms ab: Rats receiving intrahippocampal injections of 192 IgG-saporin (SAP-HPC), fimbria-fornix lesions (FF), or sham control surgeries were tested in a series of delayed matching (DMTP)- and nonmatching (DNMTP)-to-position tasks. The FF group was significantly impaired on a pretrained DNMTP task relative to the control and SAP-HPC groups, which did not differ. All groups then acquired a matching-to-position rule at the same rate, and only the FF group showed a delay-dependent deficit when longer retention intervals were introduced for DMTP testing. Results demonstrate the importance of the fimbria-fornix fiber system in spatial short-term memory but suggest that the cholinergic septohippocampal component of this pathway is not required for successful delayed matching (or nonmatching)-to-position performance. Reprinted by permission of the publisher. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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