The Mesocortical Dopamine Projection to Anterior Cingulate Cortex Plays No Role in Guiding Effort-Related Decisions.
Both mesolimbic dopamine (DA) and the anterior cingulate cortex (ACC) have been implicated in enabling animals to expend effort to obtain greater reward. To investigate the role of the DA pathway to ACC in working for reward, the authors tested rats on a cost-benefit T-maze paradigm in which they co...
| Publicado en: | Behavioral Neuroscience Vol. 119; no. 1; pp. 323 - 329 |
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| Autores principales: | , , |
| Formato: | Artículo |
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American Psychological Association
February 2005
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=506547806&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 506547806 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 07357044 BEN jtl: Behavioral Neuroscience issn: 07357044 maglogo: N pubinfo: dt: February 2005 vid: 119 iid: 1 pid: 34 pub: American Psychological Association artinfo: ui: 506547806 10.1037/0735-7044.119.1.323 ppf: 323 ppct: 6 formats: tig: atl: The Mesocortical Dopamine Projection to Anterior Cingulate Cortex Plays No Role in Guiding Effort-Related Decisions. aug: au: Walton, M. E. Croxson, P. L. Rushworth, M. F. S. su: Laboratory rats Brain function localization Dopamine Reward (Psychology) sug: subj: Laboratory rats Brain function localization Dopamine Reward (Psychology) ab: Both mesolimbic dopamine (DA) and the anterior cingulate cortex (ACC) have been implicated in enabling animals to expend effort to obtain greater reward. To investigate the role of the DA pathway to ACC in working for reward, the authors tested rats on a cost-benefit T-maze paradigm in which they could either climb a barrier to obtain large reward in 1 arm (high reward [HR]) or select the low-effort alternative containing less reward (low reward [LR]). Surprisingly, ACC DA depletions had no effect on choice performance. Manipulations of barrier and reward sizes demonstrated that lesioned rats were as sensitive to the costs and benefits of the alternatives as controls. These results imply that the DA projection to ACC is not involved in guiding effort-related decisions. Reprinted by permission of the publisher. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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