Orbitofrontal Lesions Impair Use of Cue-Outcome Associations in a Devaluation Task.
The orbitofrontal cortex (OFC) has been implicated in the use of outcome expectancies to guide behavior. The present study used a devaluation task to examine this function. Rats first received light-food pairings followed by food-toxin pairings designed to devalue the food. After either excitotoxic...
| Publicado en: | Behavioral Neuroscience Vol. 119; no. 1; pp. 317 - 323 |
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| Autores principales: | , , |
| Formato: | Artículo |
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American Psychological Association
February 2005
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=506547815&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 506547815 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 07357044 BEN jtl: Behavioral Neuroscience issn: 07357044 maglogo: N pubinfo: dt: February 2005 vid: 119 iid: 1 pid: 34 pub: American Psychological Association artinfo: ui: 506547815 10.1037/0735-7044.119.1.317 ppf: 317 ppct: 6 formats: tig: atl: Orbitofrontal Lesions Impair Use of Cue-Outcome Associations in a Devaluation Task. aug: au: Pickens, Charles L. Saddoris, Michael P. Gallagher, Michela su: Frontal lobe Brain function localization Laboratory rats sug: subj: Frontal lobe Brain function localization Laboratory rats ab: The orbitofrontal cortex (OFC) has been implicated in the use of outcome expectancies to guide behavior. The present study used a devaluation task to examine this function. Rats first received light-food pairings followed by food-toxin pairings designed to devalue the food. After either excitotoxic or sham OFC lesions, responding to the light was reassessed. Sham-lesioned rats showed reduced responding to the light relative to behavioral controls, which had received food and toxin unpaired. In contrast, OFC-lesioned rats showed no such reductions. Combined with previous data (C. L. Pickens, M. P. Saddoris, B. Setlow, M. Gallagher, P. C. Holland, & G. Schoenbaum, 2003), these results indicate that the OFC is critical for the maintenance of information about the current incentive value of reinforcers or the use of that information to guide behavior. Reprinted by permission of the publisher. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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