Mapping Conditioned Taste Aversion Associations Using c-Fos Reveals a Dynamic Role for Insular Cortex.
Novel tastes are more effective than familiar tastes as conditioned stimuli (CSs) in taste aversion learning. Parallel to this, a novel CS-unconditioned stimulus (US) pairing induced stronger Fos-like immunoreactivity (FLI) in insular cortex (IC), amygdala, and brainstem than familiar CS-US pairing,...
| Publicado en: | Behavioral Neuroscience Vol. 119; no. 2; pp. 388 - 399 |
|---|---|
| Autores principales: | , |
| Formato: | Artículo |
| Publicado: |
American Psychological Association
April 2005
|
| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=506572641&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 506572641 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 07357044 BEN jtl: Behavioral Neuroscience issn: 07357044 maglogo: N pubinfo: dt: April 2005 vid: 119 iid: 2 pid: 34 pub: American Psychological Association artinfo: ui: 506572641 10.1037/0735-7044.119.2.388 ppf: 388 ppct: 11 formats: tig: atl: Mapping Conditioned Taste Aversion Associations Using c-Fos Reveals a Dynamic Role for Insular Cortex. aug: au: Koh, Ming Teng Bernstein, Ilene L. su: Laboratory rats Taste Conditioned response Brain function localization sug: subj: Laboratory rats Taste Conditioned response Brain function localization ab: Novel tastes are more effective than familiar tastes as conditioned stimuli (CSs) in taste aversion learning. Parallel to this, a novel CS-unconditioned stimulus (US) pairing induced stronger Fos-like immunoreactivity (FLI) in insular cortex (IC), amygdala, and brainstem than familiar CS-US pairing, suggesting a large circuit is recruited for acquisition. To better define the role of IC, the authors combined immunostaining with lesion or reversible inactivation of IC. Lesions abolished FLI increases to novel taste pairing in amygdala, suggesting a role in novelty detection. Reversible inactivation during taste preexposure increased FLI to familiar taste pairing in amygdala and brainstem. The difference between temporary inactivation, which blocked establishment of “safe” taste memory, and lesions points to a dual role for IC in taste learning. Reprinted by permission of the publisher. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
|---|