Behavioral Effects of Basal Forebrain Cholinergic Lesions in Young Adult and Aging Rats.
The interactive effects of age and cholinergic damage were assessed behaviorally in young and middle-aged rats. Rats were lesioned at either 3 or 17 months of age by injection of 192 IgG-saporin immunotoxin into the medial septum and the nucleus basalis magnocellularis, and they were then tested on...
| Publicado en: | Behavioral Neuroscience Vol. 119; no. 4; pp. 933 - 946 |
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| Autores principales: | , , |
| Formato: | Artículo |
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American Psychological Association
August 2005
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=506621664&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 506621664 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 07357044 BEN jtl: Behavioral Neuroscience issn: 07357044 maglogo: N pubinfo: dt: August 2005 vid: 119 iid: 4 pid: 34 pub: American Psychological Association artinfo: ui: 506621664 10.1037/0735-7044.119.4.933 ppf: 933 ppct: 13 formats: tig: atl: Behavioral Effects of Basal Forebrain Cholinergic Lesions in Young Adult and Aging Rats. aug: au: Paban, Véronique Chambon, Caroline Jaffard, Magali su: Age factors in memory Brain function localization Laboratory rats sug: subj: Age factors in memory Brain function localization Laboratory rats ab: The interactive effects of age and cholinergic damage were assessed behaviorally in young and middle-aged rats. Rats were lesioned at either 3 or 17 months of age by injection of 192 IgG-saporin immunotoxin into the medial septum and the nucleus basalis magnocellularis, and they were then tested on a range of behavioral tasks: a nonmatching-to-position task in a T-maze, an object-recognition task, an object-location task, and an open-field activity test. Depending on the task used, only an age or a lesion effect was observed, but there was no Age × Lesion interaction. Middle-aged and young rats responded to the cholinergic lesions in the same manner. These results show that in the middle-aged rats in which cholinergic transmission was affected, additional injury to the system was not always accompanied by major cognitive dysfunctions. Reprinted by permission of the publisher. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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