Involvement of Catecholamine Neurotransmission in the Rat Anterior Cingulate in Effort-Related Decision Making.
This study examined whether catecholamine-mediated signals in the anterior cingulate cortex (ACC) contribute to effort-based decision making. Rats were tested after 6-hydroxydopamine or vehicle infusions into the ACC in a T maze cost-benefit task in which the rats could choose either to climb a barr...
| Publicado en: | Behavioral Neuroscience Vol. 119; no. 6; pp. 1687 - 1693 |
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| Autores principales: | , , |
| Formato: | Artículo |
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American Psychological Association
December 2005
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=506668370&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 506668370 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 07357044 BEN jtl: Behavioral Neuroscience issn: 07357044 maglogo: N pubinfo: dt: December 2005 vid: 119 iid: 6 pid: 34 pub: American Psychological Association artinfo: ui: 506668370 10.1037/0735-7044.119.6.1687 ppf: 1687 ppct: 6 formats: tig: atl: Involvement of Catecholamine Neurotransmission in the Rat Anterior Cingulate in Effort-Related Decision Making. aug: au: Schweimer, Judith Saft, Simone Hauber, Wolfgang su: Brain function localization Laboratory rats Choice (Psychology) sug: subj: Brain function localization Laboratory rats Choice (Psychology) ab: This study examined whether catecholamine-mediated signals in the anterior cingulate cortex (ACC) contribute to effort-based decision making. Rats were tested after 6-hydroxydopamine or vehicle infusions into the ACC in a T maze cost-benefit task in which the rats could choose either to climb a barrier to obtain a high reward in one arm or run into the other arm without a barrier to obtain a low reward. Results demonstrate that infusions of 6-hydroxydopamine induced a near total loss of tyrosine hydroxylase-positive fibers in the ACC. Unlike sham-lesioned rats, 6-hydroxydopamine-lesioned rats exhibited a reduced preference for the high-cost-high-reward response option when given the choice of obtaining a low reward with little effort. Thus, catecholamine-mediated signals in the ACC could play a role in effort-based decision making. Reprinted by permission of the publisher. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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