Electrolytic Lesions of the Nucleus Accumbens Enhance Locomotor Sensitization to Nicotine in Rats.
Electrolytic lesions of the medial core of the nucleus accumbens (NAc) in male Long-Evans rats increased spontaneous locomotion, enhanced the locomotor stimulating effect of acute 5.0 mg/kg cocaine, enhanced the development and subsequent expression of locomotor sensitization produced by repeated in...
| Publicado en: | Behavioral Neuroscience Vol. 120; no. 3; pp. 600 - 612 |
|---|---|
| Autores principales: | , |
| Formato: | Artículo |
| Publicado: |
American Psychological Association
June 2006
|
| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=506694452&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 506694452 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 07357044 BEN jtl: Behavioral Neuroscience issn: 07357044 maglogo: N pubinfo: dt: June 2006 vid: 120 iid: 3 pid: 34 pub: American Psychological Association artinfo: ui: 506694452 10.1037/0735-7044.120.3.600 ppf: 600 ppct: 12 formats: tig: atl: Electrolytic Lesions of the Nucleus Accumbens Enhance Locomotor Sensitization to Nicotine in Rats. aug: au: Kelsey, John E. Willmore, Ellen J. su: Laboratory rats Limbic system Brain function localization Nicotine Cocaine sug: subj: Laboratory rats Limbic system Brain function localization Nicotine Cocaine ab: Electrolytic lesions of the medial core of the nucleus accumbens (NAc) in male Long-Evans rats increased spontaneous locomotion, enhanced the locomotor stimulating effect of acute 5.0 mg/kg cocaine, enhanced the development and subsequent expression of locomotor sensitization produced by repeated injections of 0.4 mg/kg nicotine but not 7.5 mg/kg cocaine, and enhanced the expression of conditioned locomotion. Given that 6-hydroxydopamine lesions of the NAc typically have effects on locomotor-related processes that are opposite of those produced by electrolytic and excitotoxic lesions, these data are consistent with a hypothesis that the NAc output, especially from the core, inhibits a variety of such processes and that the DA input to the NAc enhances these processes by inhibiting this inhibitory output. Reprinted by permission of the publisher. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
|---|