Path Integration and Lesions Within the Head Direction Cell Circuit: Comparison Between the Roles of the Anterodorsal Thalamus and Dorsal Tegmental Nucleus.
Experiments were designed to determine whether 2 regions of the head direction cell circuit, the anterodorsal thalamic nucleus (ADN) and the dorsal tegmental nucleus (DTN), contribute to navigation. Rats were trained to perform a food-carrying task with and without blindfolds prior to receiving sham...
| Publicado en: | Behavioral Neuroscience Vol. 120; no. 1; pp. 135 - 150 |
|---|---|
| Autores principales: | , , |
| Formato: | Artículo |
| Publicado: |
American Psychological Association
February 2006
|
| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=506694954&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 506694954 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 07357044 BEN jtl: Behavioral Neuroscience issn: 07357044 maglogo: N pubinfo: dt: February 2006 vid: 120 iid: 1 pid: 34 pub: American Psychological Association artinfo: ui: 506694954 10.1037/0735-7044.120.1.135 ppf: 135 ppct: 15 formats: tig: atl: Path Integration and Lesions Within the Head Direction Cell Circuit: Comparison Between the Roles of the Anterodorsal Thalamus and Dorsal Tegmental Nucleus. aug: au: Frohardt, Russell J. Bassett, Joshua P. Taube, Jeffrey S. su: Animal navigation Laboratory rats Brain function localization sug: subj: Animal navigation Laboratory rats Brain function localization ab: Experiments were designed to determine whether 2 regions of the head direction cell circuit, the anterodorsal thalamic nucleus (ADN) and the dorsal tegmental nucleus (DTN), contribute to navigation. Rats were trained to perform a food-carrying task with and without blindfolds prior to receiving sham lesions or bilateral lesions of the ADN or DTN. ADN-lesioned rats were mildly impaired in both versions of the task. DTN-lesioned rats, however, were severely impaired and showed reduced heading accuracy in both task versions. These findings suggest that although both the DTN and ADN contribute to navigation based on path integration and landmarks, disruption of the head direction cell circuit at the level of the DTN has a significantly greater effect on spatial behavior than lesions of the ADN. Reprinted by permission of the publisher. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
|---|