Intra-Ventral Pallidal Glutamate Antagonists Block Expression of Morphine-Induced Place Preference.
The role of ionotropic glutamate receptors within the ventral pallidum (VP) in the expression of conditioned place preference (CPP) and motor adaptations to morphine was evaluated. VP-cannulated rats were subjected to 3 days of conditioning in which saline was paired to one distinct chamber in the m...
| Publicado en: | Behavioral Neuroscience Vol. 120; no. 5; pp. 1103 - 1115 |
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| Autores principales: | , , |
| Formato: | Artículo |
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American Psychological Association
October 2006
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=506741820&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 506741820 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 07357044 BEN jtl: Behavioral Neuroscience issn: 07357044 maglogo: N pubinfo: dt: October 2006 vid: 120 iid: 5 pid: 34 pub: American Psychological Association artinfo: ui: 506741820 10.1037/0735-7044.120.5.1103 ppf: 1103 ppct: 12 formats: tig: atl: Intra-Ventral Pallidal Glutamate Antagonists Block Expression of Morphine-Induced Place Preference. aug: au: Dallimore, Jeanine E. Mickiewicz, Amanda L. Napier, T. Celeste su: Laboratory rats Conditioned response Brain function localization Morphine sug: subj: Laboratory rats Conditioned response Brain function localization Morphine ab: The role of ionotropic glutamate receptors within the ventral pallidum (VP) in the expression of conditioned place preference (CPP) and motor adaptations to morphine was evaluated. VP-cannulated rats were subjected to 3 days of conditioning in which saline was paired to one distinct chamber in the morning and morphine (8 mg/kg ip or its vehicle) was paired to an alternate chamber in the afternoon. This induced (a) CPP expression in drug-free rats 1 day later, which was blocked by immediate pretreatments with intra-VP injections of a glutamate antagonist cocktail (DL-2-amino-5- phosphonopentanoic acid lithium salt [AP-5] + 6-cyano-7-nitroquinoxaline-2,3-dione disodium salt [CNQX]), and (b) changes in motor function expressed following an acute morphine challenge 18 days later, which were absent if preceded by a 10-day treatment with the glutamate antagonists injected unilaterally once daily in alternating hemispheres. Thus, VP ionotropic glutamate receptors are critical mediators of the expression of place preference and motor adaptations subsequent to repeated morphine exposure. Reprinted by permission of the publisher. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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