Prefrontal Control of Trace Versus Delay Eyeblink Conditioning: Role of the Unconditioned Stimulus in Rabbits (Oryctolagus cuniculus)
The conditioned eyeblink (EB) response was studied with trace conditioning procedures in rabbits (Oryctolagus cuniculus) with lesions to the medial prefrontal cortex (mPFC) or sham lesions. Three experiments were performed in which either periorbital shock or a corneal airpuff served as the uncondit...
| Publicado en: | Behavioral Neuroscience Vol. 120; no. 5; pp. 1033 - 1043 |
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| Autores principales: | , , |
| Formato: | Artículo |
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American Psychological Association
October 2006
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=506741863&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 506741863 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 07357044 BEN jtl: Behavioral Neuroscience issn: 07357044 maglogo: N pubinfo: dt: October 2006 vid: 120 iid: 5 pid: 34 pub: American Psychological Association artinfo: ui: 506741863 10.1037/0735-7044.120.5.1033 ppf: 1033 ppct: 10 formats: tig: atl: Prefrontal Control of Trace Versus Delay Eyeblink Conditioning: Role of the Unconditioned Stimulus in Rabbits (Oryctolagus cuniculus) aug: au: Oswald, Barbara Knuckley, Bryan Mahan, Kathleen su: Brain function localization Conditioned response Eyelids Reflexes Laboratory rabbits sug: subj: Brain function localization Conditioned response Eyelids Reflexes Laboratory rabbits ab: The conditioned eyeblink (EB) response was studied with trace conditioning procedures in rabbits (Oryctolagus cuniculus) with lesions to the medial prefrontal cortex (mPFC) or sham lesions. Three experiments were performed in which either periorbital shock or a corneal airpuff served as the unconditioned stimulus (US) in separate groups of sham or mPFC-lesioned rabbits. Acquisition of the EB conditioned response (CR) was faster and reached a higher asymptote with the eyeshock US than with the airpuff US. However, mPFC lesion-induced trace conditioning deficits were obtained only in the groups that received the airpuff US. All rabbits showed normal delay conditioning and extinction. These results suggest that mPFC mediates trace EB conditioning when emotional arousal is low. However, in circumstances when emotional arousal may be high (i.e., during exposure to aversive periorbital shock), other structures (such as amygdala) may be activated to permit learning even in the absence of input from mPFC. Reprinted by permission of the publisher. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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